ABSTRACT
OBJECTIVE: To evaluate in a multivariate analysis the prognostic factors associated with hematopoietic recovery and the supportive care requirements after autotransplant of progenitor cells (PC) from various sources: bone marrow (BMPC), BMPC & peripheral blood (PBPC), and PBPC alone. PATIENTS AND METHODS: A total of 570 patients with hematological malignancies and solid tumors underwent high-dose therapy followed by autotransplant. PBPC were obtained after mobilization with chemotherapy and/or cytokines. One-hundred five patients received BMPC, 217 received BMPC & PBPC and 248 PBPC alone; all of the patients received G-CSF or GM-CSF after infusion. RESULTS: In a multivariate analysis the recovery of neutrophils was adversely associated with low numbers of nucleated cells infused (P < 0.13), bone marrow progenitor cell source, and diagnosis of multiple myeloma and acute leukemia (P < 0.001). The factors that adversely affected platelet recovery were low number of nucleated cells and diagnosis of multiple myeloma and acute leukemia (P < 0.001). CONCLUSIONS: We conclude that BMPC adversely affect neutrophil recovery while low numbers of nucleated cells and diagnosis of multiple myeloma and acute leukemia adversely affect both neutrophil and platelet recovery.
Subject(s)
Bone Marrow Transplantation , Erythroid Precursor Cells , Hematologic Neoplasms/therapy , Hematopoietic Stem Cell Transplantation , Adolescent , Adult , Aged , Bone Marrow Transplantation/methods , Child , Child, Preschool , Disease-Free Survival , Evaluation Studies as Topic , Female , Graft Survival , Hematologic Neoplasms/diagnosis , Hematologic Neoplasms/physiopathology , Humans , Male , Middle Aged , Multivariate Analysis , Prognosis , Regression Analysis , Retrospective Studies , Survival Rate , Transplantation, AutologousABSTRACT
As part of our investigations on fluorine containing compounds of potential pharmacological interest, a series of N-substituted p-fluorobenzencarboxyamides, analogs of previously studied p-fluorobenzensolfonamides, was prepared. The in vitro antibacterial and antimycotic properties were also assayed. The replacement of the sulfonamide group with an isosteric carboxyamide one, was found to confer to trifluoromethylsubstituted compounds good activity against some strains of yeasts (Candida) and hyphomycetes (Tricophyton, Aspergillus, Microsporum, Epidermophyton). These compounds however are not very active against the gram-positive and gram-negative bacteria on which the corresponding sulfonanilides showed significant activity.
Subject(s)
Anti-Infective Agents/chemical synthesis , Bacteria/drug effects , Fluorobenzenes/chemical synthesis , Fungi/drug effects , Anti-Bacterial Agents , Antifungal Agents/chemical synthesis , Benzamides/chemical synthesis , Benzamides/pharmacology , Chemical Phenomena , Chemistry , Fluorobenzenes/pharmacology , Microbial Sensitivity TestsABSTRACT
Further pharmacological (antipyretic and analgesic activities) and physicochemical (pka and relative lipophilicity) studies are reported on some trifluoroacetanilides which have preliminary revealed promising activities in the animal models of acute and chronic inflammation, in analogy with the known antiinflammatory trifluoromethanesulfonanilides.
Subject(s)
Acetanilides/chemical synthesis , Analgesics/chemical synthesis , Anti-Inflammatory Agents, Non-Steroidal/chemical synthesis , Anti-Inflammatory Agents/chemical synthesis , Acetanilides/pharmacology , Animals , Chemical Phenomena , Chemistry, Physical , Fluorine/chemical synthesis , Fluorine/pharmacology , Hydrogen-Ion Concentration , Lipids , Male , Mice , Rats , SolubilityABSTRACT
In an extension of the investigations on fluorine derivatives of potential pharmacological interest, some new p-fluorobenzensulfonanilides were synthesized and screened in vitro against many species of Gram-positive and Gram-negative bacteria and against some strains of Candida albicans. Some of these compounds exhibited significant antibacterial activity. The relation between activity and structure revealed that the presence of chloro and trifluoromethyl groups in the aniline ring increases activity against Gram-positive bacteria. The acute toxicity in mice was also determined.
Subject(s)
Anti-Infective Agents/chemical synthesis , Fluorobenzenes/chemical synthesis , Sulfonamides/chemical synthesis , Animals , Anti-Bacterial Agents , Candida albicans/drug effects , Chemical Phenomena , Chemistry , Female , Fluorobenzenes/pharmacology , Gram-Negative Bacteria/drug effects , Gram-Positive Bacteria/drug effects , Lethal Dose 50 , Male , Mice , Microbial Sensitivity Tests , Sulfonamides/pharmacologyABSTRACT
The analogy with the anti-inflammatory trifluoromethane-sulfonanilides prompted us to the synthesis of a series of trifluoroacetanilides which were found to maintain the pharmacological properties of the analog sulfonanilides. Many of the obtained compounds inhibited either the carrageenin-induced rat paw edema and the adjuvant-induced arthritis; some showed better anti-inflammatory properties than indomethacin and phenylbutazone. Acute toxicity and ulcerogenic effects were significantly lower than those of reference drugs.
