High-strength cellulose-polyacrylamide hydrogels: Mechanical behavior and structure depending on the type of cellulose.

Two types of stiff and high-strength composite hydrogels possessing the structure of interpenetrating polymer networks were synthesized via free-radical polymerization of acrylamide carried out straight within the previously formed physical network of regenerated plant cellulose or bacterial cellulose (PC and BC respectively) that was swollen in the reactive solution. The mechanical behavior of synthesized hydrogels subjected to the action of compressive deformations with different amplitude values was studied. The analysis of the stress-strain curves of compression tests of the hydrogels of both types obtained in different test conditions demonstrates the substantial difference in their mechanical behavior. Both the PC- and BC-based hydrogels withstand successfully the one-shot compression with the amplitude up to 80%, but in the conditions of the multiple compression tests (cyclic compressions) during the subsequent compression acts the dramatic increase in the stiffness of the BC-based hydrogels was observed at the deformation region beyond 60%. This effect can be explained by the deep reorganization of the intermolecular structure of the material with the stress-induced reorientation of BC micro-fibrils. Submicron- and micron-scale specific features of structures of composite hydrogels of both types were studied by cryo-scanning electron microscopy to explain the peculiarities of the mechanical effects observed.

Study of N-vinylpyrrolidone-N-vinylformamide copolymers labelled with indium-113m.

The procedure of the directed synthesis of N-vinylpyrrolidone-N-vinylformamide (VP-VFA) copolymers with grafted iminodiacetate (IDA) chelating units is presented. The methods for labelling resulting conjugates with indium-113m were developed. The metal-copolymer conjugates were characterized by different physicochemical methods, including IR and NMR, viscometry, light scattering, and exclusion high-performance liquid chromatography. Parameters of radiochemical synthesis of the conjugates labelled with indium-113m were optimized. It was shown that the VP-VFA-IDA copolymer firmly binds indium-113m both in the acid and alkaline solutions, with pH of the reaction mixture having almost no effect on the complexation. VP-VFA-IDA-In conjugates were found to be unstable in histidine challenge reaction.