ABSTRACT
Acquired progressive lymphangioma (APL), or benign lymphangioendothelioma, is an unusual entity derived from vascular structures. Clinically and histopathologically it may resemble Kaposi's sarcoma and well-differentiated angiosarcoma, causing a diagnostic problem. We report an individual with APL initially diagnosed with Kaposi's sarcoma who underwent unnecessary laboratory testing. Imiquimod 5% cream stopped the progression of the lesion. Awareness of this rare entity may prevent patients from undergoing excessive testing. Imiquimod may be used as a safe, effective treatment option.
Subject(s)
Adjuvants, Immunologic/administration & dosage , Aminoquinolines/administration & dosage , Lymphangioma/diagnosis , Skin/pathology , Administration, Topical , Child, Preschool , Diagnosis, Differential , Female , Humans , Imiquimod , Lymphangioma/drug therapy , Sarcoma, Kaposi/diagnosis , Skin Neoplasms/diagnosisABSTRACT
Janus kinase inhibitors are emerging treatment alternatives in various immune-mediated diseases including alopecia universalis. Herein, we report a patient with psoriasis and alopecia universalis in whom treatment with tofacitinib led to remission of psoriasis without improvement in alopecia universalis. Despite the promising potential in alopecia areata treatment, research evaluating the efficacy of different Janus kinase inhibitors and possible prognostic factors related with a more favorable response are warranted.
