Spike-timing-dependent plasticity induction reveals dissociable supplementary- and premotor-motor pathways to automatic imitation.

Humans tend to spontaneously imitate others' behavior, even when detrimental to the task at hand. The action observation network (AON) is consistently recruited during imitative tasks. However, whether automatic imitation is mediated by cortico-cortical projections from AON regions to the primary motor cortex (M1) remains speculative. Similarly, the potentially dissociable role of AON-to-M1 pathways involving the ventral premotor cortex (PMv) or supplementary motor area (SMA) in automatic imitation is unclear. Here, we used cortico-cortical paired associative stimulation (ccPAS) to enhance or hinder effective connectivity in PMv-to-M1 and SMA-to-M1 pathways via Hebbian spike-timing-dependent plasticity (STDP) to test their functional relevance to automatic and voluntary motor imitation. ccPAS affected behavior under competition between task rules and prepotent visuomotor associations underpinning automatic imitation. Critically, we found dissociable effects of manipulating the strength of the two pathways. While strengthening PMv-to-M1 projections enhanced automatic imitation, weakening them hindered it. On the other hand, strengthening SMA-to-M1 projections reduced automatic imitation but also reduced interference from task-irrelevant cues during voluntary imitation. Our study demonstrates that driving Hebbian STDP in AON-to-M1 projections induces opposite effects on automatic imitation that depend on the targeted pathway. Our results provide direct causal evidence of the functional role of PMv-to-M1 projections for automatic imitation, seemingly involved in spontaneously mirroring observed actions and facilitating the tendency to imitate them. Moreover, our findings support the notion that SMA exerts an opposite gating function, controlling M1 to prevent overt motor behavior when inadequate to the context.

Insights from Chilean NCDs Hospitalization Data during COVID-19.

The COVID-19 pandemic has affected the lifestyles of people of all ages, conditions and occupations. Social distance, remote working, changes in diet and a lack of physical activity have directly and indirectly affected many aspects of mental and physical health, particularly in patients with many comorbidities and non-communicable diseases (NCDs). In our paper, we analyzed COVID-19 hospitalized and non-hospitalized cases according to comorbidities to assess the average monthly percentage change (AMPC) and monthly percentage change (MPC) using open access data from the Chilean Ministry of Science, Technology, Knowledge and Innovation. As expected, the infection mainly affected patients with comorbidities, including cardiovascular risk factors. The hospitalized cases with obesity and chronic lung disease increased throughout the period of June 2020-August 2021 (AMPC = ↑20.8 and ↑19.4%, respectively, p < 0.05), as did all the non-hospitalized cases with comorbidities throughout the period (AMPC = ↑15.6 to ↑30.3 [p < 0.05]). The increases in hospitalizations and non-hospitalizations with comorbidities may be associated with physical inactivity. A healthy lifestyle with regular physical activity may have had a protective effect on the COVID-19 severity and related events in the post-pandemic period, especially for the NCD population.

On pharmacological neuroenhancement as part of the new neurorights' pioneering legislation in Chile: a perspective.

The so-called neurorights are emerging human rights, or rather reconfigurations of already existing human rights, seeking to address the impact of the possible misuse of neurotechnologies, which have the potential to become more invasive and harmful in the future if not regulated. The aim of specifying neurorights is to protect the dignity and autonomy of the individual in the face of neurotechnological advances. Recently, Chile proposed a Constitutional reform inspired by the neurorights, opening a debate. One of the proposed neurorights is fair and equitable access to cognitive enhancement, which will be the specific object of this perspective article. Starting from the legal proposal, we analyse and discuss some perspectives on cognitive enhancement, or "neuroenhancement", which could be considered as part of enhancement neurotechnologies, pointing out that pharmacological enhancers, or "smart drugs", might be considered as part of these enhancers. We present a classification of the different types of cognitive enhancements as it has been proposed in the literature, into which pharmacological cognitive enhancement can be included, concluding that there is currently no agreement amongst scholars and lawyers about the ethical consideration of pharmacological cognitive enhancement. We therefore argue that it is necessary for the legislator to explicitly address the issue in the proposed regulations, in order to take a clear position on the topic, as it has been done in the United Kingdom, where the pharmacological neuroenhancers have been explicitly excluded from the regulation. If pharmacological neuroenhancers are going to be considered neurotechnologies, then new law proposals should seek harmonization with the already existing legislation regulating pharmacological health and consumer rights (both globally, taking into account international drug laws, and locally, according to each country's internal regulations) and of course, with the whole system of fundamental rights. Finally, we briefly discuss the ethical problem of equitable access to this new type of neurotechnologies (as part of the neurorights) and leave the debate open for new insights from the scientific community on the possible consequences of including (or not) pharmacological neuroenhancers as neurotechnologies for cognitive enhancement in the framework of the ethical and legal debate.

Risk Perception Influence on Vaccination Program on COVID-19 in Chile: A Mathematical Model.

The SARS-CoV-2 virus emergency prompted unprecedented safety measures, which were accepted by the population of each country to different degrees, for example, with more or less willingness to use personal protective elements (PPEs). We have developed a mathematical model of the contagion process, based on chilean data, to assess the interaction between biological factors (such as the impact of vaccination) and behavioral factors (such as the population's perception of risk). The model clearly shows that the virus spreads through three waves of contagion, the second being the most prominent, regardless of any alteration in the variables taken into account, which only affect the overall number of people infected. By considering alternative values of the risk perception variable and examining the different possible scenarios, we have also found that the less reaction to change the population has (and the lower the disposition to use PPEs), the higher the waves of contagion and the death toll are.

Affective modulation of cognitive control: A systematic review of EEG studies.

In recent years, a growing corpus of research has been conducted utilizing a variety of behavioral and neurophysiological methodologies to investigate the relationship of emotion and cognition, yielding unique insights into fundamental concerns about the human mind and mental disease. Electroencephalography (EEG) has been utilized to investigate how emotional states alter neural markers of cognitive control. The current study is a systematic analysis of EEG research that looks at affective modulation (mood, emotion) of cognitive control and its many sub-processes (e.g., cognitive flexibility, inhibitory control, and working memory). The PRISMA standards were followed in this review, which looked at experimental designs and tasks, as well as methodological elements of EEG recording and analysis across research. A total of 35 articles were chosen for qualitative synthesis as a consequence of the search. The examination of event-related potentials (ERPs), which showed affective modulation of 19 different components, was the most common electrophysiological approach used across research. The majority of the investigations focused on N2 and P3, indicating that affective induction has a strong influence on attentional processes and response inhibition. Future research should look into different methodologies such as source location and connection metrics to better understand the brain's areas and dynamic response during affective induction activities. It is also suggested that the technical components of the report be more explicit in order to promote study comparability and replication.

Levels of Polychlorinated Dibenzo-p-Dioxins/Furans (PCDD/Fs) and Dioxin-Like Polychlorinated Biphenyls (DL-PCBs) in Human Breast Milk in Chile: A Pilot Study.

Persistent organic pollutants (POPs) are organic compounds that resist biochemical degradation, moving long distances across the atmosphere before deposition occurs. Our goal was to provide up-to-date data on the levels of polychlorinated dibenzo-p-dioxins/furans (PCDD/Fs) and dioxin-like polychlorinated biphenyls (DL-PCBs) in breast milk from Chilean women and to estimate the exposure of infants due to breast milk consumption. In Chile, we conducted a cross-sectional study based on methodologies proposed by the WHO, with a sample of 30 women recruited from three defined areas: 10 from the Arica Region (urban; Arica and Parinacota Region), 10 from Coltauco (rural; O'Higgins Region), and 10 from Molina (40% rural; Maule Region). High-resolution gas chromatography coupled with high-resolution mass spectrometry (HRGC/HRMS) was performed on pooled samples from each area. We calculated equivalent toxic concentrations (WHO-TEQ) based on the current WHO Toxic Equivalency Factors (TEF). The minimum and maximum values of ∑ PCDDs/Fs + DL-PCBs-TEQ were 4.317 pg TEQ/g fat in Coltauco and 6.31 pg TEQ/g fat in Arica. Molina had a total TEQ of 5.50 pg TEQ/g fat. The contribution of PCDD/Fs was approximately five-fold higher than that of DL-PCBs. The Estimated Daily Intake (EDI) of ∑ PCDDs/Fs + DL-PCBs based on the three pooled samples ranged between 6.71 and 26.28 pg TEQ/kg body weight (bw)/day, with a mean intake of 16.11 (±6.71) pg TEQ/kg bw/day in breastfed children from 0 to 24 months old. These levels were lower than those reported in international studies. Despite the fact that the observed levels were low compared to those in most industrialized countries, the detection of a variety of POPs in breast milk from Chilean women indicates the need for follow-up studies to determine whether such exposures during childhood could represent a health risk in adulthood.

[Pesticide exposure in Chile and population health: urgency for decision making]. / Exposición a plaguicidas en Chile y salud poblacional: urgencia para la toma de decisiones.

In the last 25 years, Chile has had an expanding role as an agro-export country in the global economy, with efficient rates of productivity in the region, based on the technological development of agriculture, with of large monocultures whose productivity depends on the intensive application of agrochemicals. This form of agriculture has also lacked efficient regulations and surveillance, so it is difficult to estimate the real magnitude of the exposed population and its effects on health in the short or long term. This systematic review compiles the epidemiological evidence generated from studies conducted in several regions of Chile regarding pesticide exposure and health effects. Of the total number of articles, 50% included agricultural workers, 25% children, and 25% women of childbearing age, with the greatest effects being the neurotoxic (54%), genotoxic (31%) and reproductive (15%). The evidence collected shows that in Chile the levels of exposure to pesticides in the general and occupational population are higher than international studies levels. It is urgent to protect the health of both the occupational and general population and especially children through a stricter control of the sale and use of pesticides, with comprehensive surveillance systems in environmental health and educational actions in the social and cultural context of rural communities. It is a priority to strengthen research with national relevance on health effects, and strictly restrict the use of pesticides already prohibited in developed countries due to their high level of risk to human and environmental health.

Aspectos éticos del uso de identificadores biométricos / Bioethical aspects of the use of biometric identifiers / Aspectos éticos do uso de identificadores biométricos

La biometría ha tenido una rápida expansión como tecnología, siendo cada vez más accesible para el público general, prestando utilidad a los gobiernos y a la sociedad en el manejo de la seguridad ciudadana. Se aplica para la verificación o la identificación de la identidad de un individuo y, desde un punto de vista puramente técnico, constituye un problema de reconocimiento de patrones. En Chile, el marco legal acerca del manejo de datos personales no incluye específicamente a la biometría. A la fecha, se encuentra en trámite un nuevo proyecto de ley que considera tanto los datos biométricos como los perfiles biológicos. En otros países, los informes de las últimas dos décadas, que analizan el uso de biometría, plantean como principal foco de preocupación, desde el punto de vista ético, el derecho a la privacidad de los individuos, entregándose orientaciones prácticas acerca de la aplicación apropiada de estas tecnologías. Finalmente, desde un breve análisis de la biopolítica, se contextualiza el papel que cumple la biometría y los requerimientos éticos básicos para su desarrollo en dicho marco.

Biometrics has had a rapid expansion as a technology, being increasingly accessible to the public, and lending utility to governments and society in the management of citizen security. It is applied either for verification or for identification of an individual's identity and technically constitutes a problem of pattern recognition. In Chile, the existing legal framework regarding the handling of personal data does not include specific biometrics in its regulation. A new bill that considers both biometric data and Biological profiles is in process. In addition, we revised the international reports of the last two decades that analyze the use of biometrics. The primary focus of concern of these documents, from the ethical point of view, is the right to privacy of individuals, giving practical guidance and discussion regarding the elements necessary for the application of these novel technologies in an appropriate ethically manner. Finally, we contextualize from a brief analysis of biopolitics the role of biometrics and the basic ethical requirements for its development in that framework.

A biometria teve uma rápida expansão como tecnologia, sendo cada vez mais acessível para o público geral, sendo de utilidade para os governos e à sociedade no manejo da segurança cidadã. Ela pode ser aplicada para a verificação ou estabelecimento da identidade de um indivíduo e, desde um ponto de vista puramente técnico, constitui um problema de reconhecimento de padrões. No Chile, o contexto legal acerca do manejo de dados pessoais não inclui especificamente a biometria. Atualmente, encontra-se tramitando um novo projeto de lei que considera tanto os dados biométricos como os perfis biológicos. Em outros países, os informes das últimas duas décadas que analisam o uso da biometria, propõem como principal foco de preocupação, do ponto de vista ético, o direito à privacidade dos indivíduos, entregando-se orientações práticas acerca da aplicação apropriada destas tecnologias. Finalmente, desde uma breve análise da bio-política, contextualiza-se o papel que cumpre a biometria e os requerimentos éticos básicos para seu desenvolvimento em tal contexto legal.

Differential involvement of left and right frontoparietal areas in visuospatial planning: An rTMS study.

The planning process consists of pre-determining an ordered series of actions to accomplish a goal. Previous research showed that the left prefrontal cortex (PFC) is likely to create the strategy for a plan, while the right PFC could be relevant for its update. These roles for the two PFCs need to be ascertained for visuospatial planning, whether communalities or differences exist with other planning tasks. Moreover, the contribution of the posterior parietal cortex (PPC) to planning still lacks evidence. Online repetitive transcranial magnetic stimulation (1 Hz) was used, and 32 participants were involved in the visuospatial planning task in a within-subject design to inhibit either the frontal or the parietal cortex of either the left or the right hemisphere. The goal consisted of evaluating the contribution of these cortical regions, also controlling for gender, in a computerized version of the travelling salesman problem (TSP), the "Maps" task. The results showed that all the stimulated sites produced significant differences in their involvement, reflected in several parameters (such as initial planning and execution times, strategies and heuristics used), with respect to the control group. The roles for the two PFCs were generally confirmed in all measures except path length, while the contribution of the PPC emerged throughout the measures related to the ongoing execution. We concluded that the results obtained with the TSP paradigm were consistent with results obtained using other tasks used to study the planning process (such as the Tower of London) for the evaluation of PFC contribution. In addition, we showed that the contribution of the PPC to the planning process has probably been underestimated.

Validity and Reliability of an Assessment Tool for the Screening of Neurotoxic Effects in Agricultural Workers in Chile.

There is a substantial use of pesticides within the agricultural industry of Chile, with neurotoxic effects through mechanisms of acetylcholinesterase inhibition. These pesticides result in deterioration in health, increasing the risk of diseases such as Parkinson's and Alzheimer's in highly exposed occupational population. To date, there are no brief assessment tools to monitor cognitive impairment in agricultural workers chronically exposed to these pesticides. Method. 234 agricultural workers and 305 nonagricultural workers were assessed two times (test-retest) through a brief tool which comprised three tests (clock-drawing test (CDT); frontal assessment battery (FAB); trail making tests (TMT) A and B). The full scale of WAIS-IV was administered as a gold standard to 18% of the sample of agricultural workers. Factor analysis was used to evaluate the factor structure, and validity and test-retest reliability were assessed concurrently. Results. Cronbach's alpha values were satisfactory or above (>0.60). Test-retest correlations were all significantly correlated (p < 0.001). All the tests had a significant correlation with the full scale IQ score of WAIS-IV (p < 0.05). The Kaiser-Meyer-Olkin (KMO) measure was 0.74, and the Bartell sphericity test = p < 0.001. Three factors explaining 61.62% of the variance were extracted. Two items of the FAB test were dropped of the final factor solution. Normative data transformed into percentile scores and stratified by age and educational level were obtained for Chilean agricultural workers. Conclusion. The brief assessment tool has adequate metric properties as a screening instrument. This allows for a simple administration test (10 to 15 minutes) that can potentially be used for the rapid monitoring of cognitive deterioration in the face of occupational exposure to pesticides in agricultural workers.

Performance predictions and postdictions in prospective memory of school-aged children.

Prospective memory (PM) undergoes important developmental changes during the primary school years, particularly around 7 and 8 years of age. Recent studies have suggested that, as well as executive functions (EFs), PM development also benefits from age-related increments in metamemory (MM) abilities. The primary aim of the current study was to explore the role of MM monitoring and control processes (i.e., procedural MM) of 7- and 8-year-old children in a PM task including specific cues. Monitoring processes were assessed by asking children to judge their own PM performance before (predictions) and after (postdictions) in performing a PM task. In addition, children were asked to report the strategy they used to remember the PM task. Reactive effects of making predictions and using strategies were assessed via both an ongoing task (OT) and PM performance. EF and declarative MM performance was also examined. Results showed that children who were asked to predict PM performance had faster PM response times (RTs), but not higher accuracy rates, than children in a control group. However, strategy use affected both PM and OT performance, with those children reporting active strategy use obtaining higher PM accuracy rates and slower OT RTs. Finally, switching abilities were also predictive of OT performance. This investigation highlights the importance of studying MM monitoring and control processes in relation to children's PM.

Laboratory of the Neuropsychology and Cognitive Neurosciences Research Center of Universidad Católica del Maule, Chile.

The Laboratory of the Neuropsychology and Cognitive Neurosciences Research Center (CINPSI Neurocog), located in the "Technological Park" building of the Catholic University of Maule (Universidad Católica del Maule, UCM) campus in Talca, Chile, has been established as "Psychology Lab" recently in July, 2016. Our lines of work include basic and applied research. Among the basic research, we study executive functions, decision-making, and spatial cognition. In the applied field, we have studied neuropsychological and neurobehavioral effects of pesticides exposure, among other interests. One of our aims is to develop collaboration both national and internationally. It is important to mention that to date there are only few psychology laboratories and research centers in Chile involved with the fields of neuropsychology and neurosciences. Thus, this scientific effort could be a groundbreaking initiative to develop specific knowledge in this area locally and interculturally through its international collaborations.

Action imitation changes perceptual alternations in binocular rivalry.

Binocular rivalry is a visual phenomenon in which perception alternates between two different monocular images presented to each of the two eyes. Here, we propose using this phenomenon as a method to study the relation between action execution and action perception. In our experiment, a simple background (a checkerboard) was contrasted with a video representing a hand continuously grasping and releasing a ball. In Experiment 1, our subjects were asked to reproduce the perceived movement with their right hand whenever they became aware of it and to stop doing this when the checkerboard dominated. Our results revealed that motor imitation of the perceived action significantly increased the time spent perceiving the hand. Three control experiments showed that these effects were not due to a generic involvement of focused attention (Experiment 2 and 3), to a verbal description of the performed action (Experiment 3) or to the execution of an unrelated movement of the hand (Experiment 4). Although an intrinsic connection between action execution and attention cannot be excluded with certainty, and the boundary between action imitation and unrelated action execution may vary along various degrees of similarity, on the whole, the present results seem to suggest, at least on a preliminary basis, that action imitation do play a relevant role in the perception of action. We discuss these findings in the frame of current theories concerning the relation between perception and action.