1.
Eksp Klin Farmakol
; 56(2): 47-50, 1993.
Article
in Russian
| MEDLINE
| ID: mdl-7688624
ABSTRACT
The antiallergic effects of new novel synthetic coumarine-3-carboxylic acid derivatives were studied in a rat model of passive cutaneous anaphylaxis. The most potent agent was found and tested for mechanisms of its specific pharmacological action. Its capacity of suppressing immediate hypersensitivity in various animal species was demonstrated to be due to its concomitant action on the pathochemical and pathophysiological stages of the allergic process.
Subject(s)
Coumarins/therapeutic use , Hypersensitivity, Immediate/drug therapy , Anaphylaxis/drug therapy , Anaphylaxis/immunology , Animals , Bronchial Spasm/drug therapy , Bronchial Spasm/immunology , Coumarins/chemistry , Drug Evaluation, Preclinical , Female , Guinea Pigs , Histamine Release/drug effects , Hypersensitivity, Immediate/immunology , Male , Mice , Mice, Inbred CBA , Muscle Contraction/drug effects , Muscle, Smooth/drug effects , Passive Cutaneous Anaphylaxis/drug effects , Rabbits , Rats , Structure-Activity Relationship
2.
Farmakol Toksikol
; 54(5): 27-9, 1991.
Article
in Russian
| MEDLINE
| ID: mdl-1800140
Subject(s)
Aminophylline/pharmacology , Theophylline/pharmacology , Aminophylline/administration & dosage , Aminophylline/pharmacokinetics , Aminophylline/toxicity , Animals , Bronchial Spasm/chemically induced , Bronchial Spasm/drug therapy , Capsules , Chemistry, Pharmaceutical , Drug Compounding , Female , Guinea Pigs , Male , Mice , Rabbits , Tablets , Theophylline/administration & dosage , Theophylline/pharmacokinetics , Theophylline/toxicity
3.
Fiziol Zh SSSR Im I M Sechenova
; 74(9): 1337-40, 1988 Sep.
Article
in Russian
| MEDLINE
| ID: mdl-3215340