ABSTRACT
In experimental study, in white rats with carbon tetrachloride-induced injury of the liver, branched-chain amino acids of vegetable origin were found to display hepatoprotective activity against the CCL4 toxic effect. They reduced the ammonia and glutamine concentrations in the blood and brains of the experimental animals and caused a significant decrease in the concentration of the aromatic amino acids (phenylalanine and tyrosine) in the animals' brains. The results of the study indicate that branched-chain amino acids are related to the pathogenesis of hepatic encephalopathy.
Subject(s)
Amino Acids, Branched-Chain/administration & dosage , Liver Cirrhosis, Experimental/metabolism , Nitrogen/metabolism , Animals , Brain/metabolism , Carbon Tetrachloride , Hepatic Encephalopathy/etiology , Liver Cirrhosis, Experimental/chemically induced , Rats , Rats, WistarABSTRACT
Phosphatidylinositol-specific phospholipase C (PIPLC) from Bacillus thuringiensis (0.11 units per ml) inhibited growth of IC-Sofia carcinoma cell line in culture by 64%. The growth of transplanted carcinoma in hamsters was also inhibited by 29% at a dose of 4.9 units of PIPLC/kg animal/day. In addition, degeneration processes and a significant fibrosis of the tumour occurred. The functional, clinical, biochemical and haematological parameters studied were consistent with the established antitumour effect in vivo.
