Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 2 de 2
Filter
Add more filters










Database
Language
Publication year range
1.
Eur Biophys J ; 50(8): 1069-1081, 2021 Dec.
Article in English | MEDLINE | ID: mdl-34455461

ABSTRACT

The sensitivity of protein molecular structures makes them susceptible to aggregation in conditions unfavorable for the maintenance of their native folds. The aggregation of proteins leads to many disorders, but the inhibition of amyloid fibril formation using metal-containing small molecules is gaining popularity. Herein we report the effect of nickel(II) complexes (N1, N2, N3, and N4) bearing thiosemicarbazones on the inhibition of amyloid fibril formation by insulin. The interactions of the complexes with amyloid fibrils were investigated using various biophysical techniques, including light scattering, intrinsic fluorescence assay, thioflavin T (ThT) assay, and Fourier transform-infrared spectroscopy. The results revealed that the phenyl-substituted N3 was an efficient inhibitor of amyloid fibril formation and maintained the insulin in its native structure despite conditions promoting fibrillation. Nickel(II) complexes containing indole based thiosemicarbazones were efficient in inhibiting the amyloid fibril formation and maintaining the insulin in its native structure in unfavorable conditions.


Subject(s)
Amyloid , Thiosemicarbazones , Fluorescence , Insulin , Nickel , Thiosemicarbazones/pharmacology
2.
Acta Crystallogr E Crystallogr Commun ; 73(Pt 4): 594-597, 2017 Apr 01.
Article in English | MEDLINE | ID: mdl-28435728

ABSTRACT

The crystal structures of two title Schiff base derivatives, C15H12N4O·C2H6O (1·EtOH) and C13H13N3O2S (2), were determined at 110 and 100 K, respectively. In the crystal of compound 1·EtOH, the (E)-N'-[(1H-indol-3-yl)methyl-idene]isonicotinohydrazide and ethanol mol-ecules are linked by O-H⋯O, N-H⋯O and N-H⋯N hydrogen bonds, forming a tape structure running along the b-axis direction. The tapes are weakly linked via a C-H⋯N inter-action. In the crystal of compound 2, (E)-N-methyl-2-[1-(2-oxo-2H-chromen-3-yl)ethyl-idene]hydrazinecarbo-thio-amide mol-ecules are linked via N-H⋯O and C-H⋯O hydrogen bonds, forming a helical chain along the b-axis direction. The chains are further linked into a layer expanding parallel to (102) through C-H⋯S inter-actions.

SELECTION OF CITATIONS
SEARCH DETAIL
...