[Efficiency of Siberian pine oil in complex treating of people ill with benign hypertension].

For people ill with benign hypertension and going through basis hypotensive therapy, taking in Siberian pine nut oil as much as 17,5 g per day, is accompanied by cholesterol-lessening effect, normalization of lipid spectrum of blood, systolic (maximum) benign pressure and lessening of surplus body mass.

[Hepatoprotectors prevent the toxic action of cyclophosphamide on the liver of rats with CCl4-induced hepatitis model].

The results of experiments on white rats with CCl4-induced hepatitis showed that the combined introduction of cyclophosphamide and hepatoprotectors of the plant origin (lochein, maksar, silimarin) leads to a decrease in acute toxicity and to less pronounced manifestations of hepatotoxicity of cyclophosphamide. Hepatoprotectors decrease the activity of aminotransferases, reduce the level of bilirubin, normalize the content of protein andpipids in the blood serum, and suppress the development of morphological disorders in the liver.

[Hepatoprotector properties of polyphenolic complexes from wood and cell culture of Maackia amurensis].

Polyphenolic complexes (PPCs) extracted from core wood and cell culture of Maackia amurensis decrease the acute toxicity of tetrachloromethane, suppress the necrosis of hepatocytes and the cellular infiltration in liver parenchyma, prevent the development of fatty and protein dystrophy in the liver, normalize the activity of aminotransferases and gamma-glutamyltransferase in the blood, restore the protein and lipid content, and stimulate the conjugation of bilirubin. The therapeutic effect was more pronounced for the PPC obtained from the cell culture. The hepatoprotector effect of the PPCs is due to the presence of isoflavonoids, including daidzein, retusin, genistein, afromosin, formononetin, orobol, tektorigenin, maakiain, and medicarpin. Ther PPC from the cell culture of Maackia amurensis does not affect the blood cholesterol level, which is probably explained by the absence of mono- and dimeric stilbenes in this cell culture.

[Combined treatment with reaferon and iodantipirin in patients with chronic viral hepatitides B and C].

AIM: To examine clinical efficacy of combined therapy with reaferon and iodantipirin in patients with chronic hepatitis B and C of moderate activity. MATERIAL AND METHODS: 100 patients with confirmed diagnosis of chronic viral hepatitis (CVH) at the stage of replication. All the patients have undergone puncture biopsy of the liver with estimation of index of histological activity Knodell and index of fibrosis Desmeth. RESULTS: Comparative evaluation was made of clinical efficacy of combined therapy reaferon + iodantipirin and monotherapy with reaferon in 100 patients with moderate activity CHB and C. CONCLUSION: Conventional scheme with reaferon turned out less effective than the above combination therapy.

[The effect of hepatoprotectors containing phospholipids on rats with experimental acute pancreatitis]. / Terapevticheskii éffekt gepatoprotektorov, soderzhashchikh fosfolipidy, pri éksperimental'nom ostrom pankreatite.

The experiments on rats with a model acute pancreatitis showed that hepatoprotectors containing phospholipids (eplir and essentiale) improve the parameters of metabolism and the functions and histological characteristics of the pancreas and liver. Both drugs produced an antioxidant effect, decreased the activity of alpha-amylase, lipase, enzymes of hepatic origin in the blood, and reduced the content of creatinine, glucose, urea, bilirubin, and lipids. The therapeutic action of eplir was more pronounced than that of essentiale.

[Effect of the phytohepatoprotective agent maxar on the hepatic morphofunctional status in patients with chronic hepatitis]. / Vliianie fitogepatoprotektora maksara na morfofunktsional'noe sostoianie pecheni u bol'nykh khronicheskim gepatitom.

The paper provides evidence for that as compared with the well-known drug carsil, the new Russian phytohepatoprotective agent maxar has a therapeutic efficiency in patients with mild and moderate chronic hepatitis (CH) of viral and alcoholic etiology. Maxar has been found to produce a more pronounced hepatoprotective effect, to a greater extent, in CH of alcoholic etiology.

[Efficacy of enzyme-inducing agents in experimental tetrachloromethane poisoning]. / Effektivnost' fermentindutsiruiushchikh sredstv pri éksperimental'nom porazhenii pecheni tetrakhlorometanom.

Liver monooxygenase system inductors benzonal, galonal, and galodif exceed phenobarbital and zixorin in therapeutic efficacy with respect to rats poisoned with tetrachloromethane. The former drugs increase the content and catalytic activity of cytochrome P-450, improve conjugation with reduced glutathione, prevent the cytolysis of hepatocytes, and stimulate the bile secretion and the liver excretion function.

[Hemorheological effects of polyethylene oxide in rats with acute myocardial ischemia]. / Gemoreologicheskie éffekty poliétoksa u krys s ostroi ishemiei miokarda.

The effect of polyetox, a medicinal form of high-molecular-weight poly(ethylene oxide) (HMWPEO) on the rheological properties of blood and the necrotic zone size was studied in rats with an acute myocardial ischemia model (on the 5th day after coronary artery occlusion). The drug was infused intravenously in a single daily dose over a period of three days, which resulted in a final HMWPEO concentration of 1 x 10(-6) g/ml in the blood. The first treatment was carried out 1 h after coronary artery occlusion. Animals in the cotrol group with myocardial infarction exhibited high blood viscosity syndrome with stable decrease in the hydrodynamic index. The administration of polyetox reduced blood viscosity, decreased the erythrocyte aggregation, and increased the antiturbulent properties (hydrodynamic index) of the blood. The myocardial infarction zone decreased by 38%, which was manifested in improved EEG parameters.

[Preclinical study of maxar safety]. / Doklinicheskoe izuchenie bezopasnosti maksara.

The results of preclinical safety evaluation of the new hepatoprotector maxar showed that this drug can be classified as a low-toxicity substance with respect to acute toxicity. No significant functional and structural changes in the systems and organs of experimental animals were observed after a 6-month administration in rats (in a dose of 300, 600, and 1200 mg/kg) and in dogs (500 mg/kg). Maxar exhibited no mutagen and allergen properties, produced no immunotoxicant action, and did not adversely affect the reproduction function.

[Hepatoprotective properties of liproxol]. / Gepatoprotektornye svoistva liproksola.

The experiments on rats with a model toxic liver damage (tetrachloromethane hepatitis) showed evidence of a high hepatoprotector activity of liproxol, representing a combination of eplir and lokhein mixed in a 1-12 ratio. Liproxol inhibits lipid peroxidation, stimulates the excretory and detoxicant functions of liver, reduces hyperfermentation, and normalized membrane phospholipid composition.

[Dependence of galodif pharmacokinetics on duration of its administration]. / Farmakokinetika galodifa pri razlichnoi prodolzhitel'nosti ego vvedeniia.

Pharmacokinetics of the new antiepileptic drug galodif was experimentally studied on rats. A single administration of the anticonvulsant is followed by slow elimination. A five-day administration leads to a significant acceleration of the drug elimination due to activation of the cytochrome P-450 dependent monooxygenase system of liver. After a 14-day administration, the elimination rate decreases as compared to that for the five-day treatment, while being still higher than in the case of single administration.

Halonal is a phenobarbital inductor of the monooxygenase system.

Experiments on rats demonstrated induction of the hepatic monooxygenase system with halonal. The effects of halonal and phenobarbital on the contents of cytochrome P-450 and its isoform P-450b+e and on the rate of substrate metabolism were similar. This suggests that enzyme-inducing activity of halonal is determined by the effect of its major metabolite. It cannot be excluded that halonal molecules possess intrinsic enzyme-inducing activity.

Efficiency of enzyme-inducing agents in rats with intrahepatic cholestasis.

Inductors of the monooxygenase system benzonal, halonal, and halodif prevented the development of intrahepatic cholestasis induced by a-naphthylisothiocyanate and stimulated detoxifying function of the liver in rats. These agents increased the content of microsomal protein and cytochrome P-450 and accelerated metabolism of types I and II substrates. This was accompanied by a decrease of serum concentrations of total and free bilirubin and activity of liver-specific enzymes. Phenobarbital did not prevent the development of hepatocyte cytolysis.

Liver damages during experimental acute pancreatitis.

Acute pancreatitis in rats caused by cooling of the pancreas with chloroethyl is characterized by the development of focal necrosis and activation of lipid peroxidation in the liver, activation of blood aminotransferase and acid and alkaline phosphatase, and increase in total and indirect bilirubin concentrations.

[Enteric sorbents potentiate hepatoprotective effect of eplir in experimental toxic hepatitis]. / Enterosorbenty usilivaiut gepatozashchitnoe deistvie éplira pri éksperimental'nom toksicheskom gepatite.

The administration of eplir (a phospholipid-containing hepatoprotector), as well as of the enterosorbents polyphepan and EST-1 (an agent obtained from dry peat extract), to rats with tetrachloromethane-induced hepatitis protect the liver parenchyma against dystrophy, necrosis, and inflammation, reduce hyperfermentemia, decrease the blood bilirubin, ammonia, phenols, and malonaldehyde, and increase the urea content in blood serum, while not fully restoring all these biochemical parameters on the normal level. The treatment of rats with toxic hepatitis by a combination of eplir and enterosorbents is accompanied by a synergistic increase in the therapeutic efficacy of each component, leading to normalization of the biochemical parameters reflecting the functional slate of liver.

[Scanning electron microscopy of peripheral blood erythrocytes in the diagnosis and treatment of hemorrhagic vasculitis in children]. / Metod skaniruiushchei élektronnoi mikroskopii éritrotsitov perifericheskoi krovi v diagnostike i lechenii gemorragicheskogo vaskulita u detei.

Twenty-four children aged 3-15 years were examined, 16 of these with cutaneous and articulo-cutaneous hemorrhagic vasculitis (HV) and 8 normal controls. The patients were divided into 2 groups: 10 patients treated by basic therapy and 6 children whose treatment protocols were supplemented by membranoprotector locheine. The children were repeatedly examined 1 month after discharge from hospital. Scanning electron microscopy of peripheral blood erythrocytes provides valuable diagnostic data on erythrocyte membrane morphology and function in children with HV and can serve as a method for monitoring the efficiency of new approaches to therapy of this disease.

[Effect of ammonium succinate on pharmacological effects of acetylsalicylic acid]. / Vliianie ammoniia suktsinata na farmacologicheskie éffekty kisloty atsetilsalitsilovoi.

Ammonia succinate potentiates the main pharmacological properties and reduces the toxic effects (ulcerogenic action and general toxicity) of acetylsalicylic acid. The new preparation astam, representing a combination of acetylsalicylic acid with ammonia succinate in a 2:1 ratio, is proposed. Astam exhibits antiexudative, capillary-reinforcing, antiproliferative, pain-relieving, antipyretic, antiaggregant, and antioxidant properties. In addition, the drug inhibits the development of structural-metabolic disorders in the case of chronic immune inflammation of joints and various internal organs.

[Therapeutic effect of hepatoprotectors in experimental Reye syndrome]. / [Gepatoprotektory okazyvaiut lechebnoe deistvie pri éksperimental'nom sindrome Reie]

Maxar and legalon--hepatoprotectors containing polyphenols--exhibit a therapeutic effect with respect to the experimental Reye's syndrome induced in rats by intraperitoneal injections of 4-pentenoic acid. Maxar restores the activity of enzymes of the hepatic origin, normalizes the content of bilirubin, glucose, phenols, and malonic aldehyde in the blood serum, stimulates the production of ketone bodies and ammonia detoxication, and improves the histologic structures of liver and cortex. Legalon also decreases the structural-metabolic disorders accompanying the Reye's syndrome, but to as lower ewxtent.

Experimental models of Reye's syndrome.

Intraperitoneal administration of 4-pentenoic acid (20 mg/kg/day for seven days or ten doses of 50 mg/kg with 4 h intervals) or acetylsalicylic acid (50 mg/kg 1 hour after single pyrogenal injection) to rats reproduced metabolic disorders characteristic of Reye's syndrome: hyperenzymemia, hyperbilirubinemia, decreased levels of ketone bodies and urea, hypoglycemia, hypoproteinemia, accumulation of ammonia and phenol, and acidosis. Necroses and microvesicular steatosis were found in the liver.

[Lochein - a novel hepatoprotective drug]. / Lokhein - novyi preparat pri lechenii zabolevanii pecheni.

A trial of a novel hepatoprotective plant drug lochein (Salsola extract) developed in Russia was performed in 110 patients with a verified chronic hepatitis of viral (73 patients) or alcohol (36 patients) etiology versus well-known hepatoprotector corsil given to 40 patients. Lochein demonstrated more potent effect than corsil.