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Bioorg Med Chem Lett
; 14(4): 1023-6, 2004 Feb 23.
Article
in English
| MEDLINE
| ID: mdl-15013015
ABSTRACT
A series of 4-substituted anilides with human melatonergic affinity is reported. Butyramides 26, 39, 42, 52, 57, and 58 all demonstrated subnanomolar MT(2) binding affinity and MT(2) selectivity of at least 70-fold over the MT(1) receptor. Compound 26 demonstrated full agonism at the MT(2) receptor.
