ABSTRACT
Hepatitis C virus (HCV) infection is a significant public health problem affecting 58 million people worldwide, including 3.9 million in Europe. Many of these infections go undiagnosed because chronic infection is often asymptomatic. This observational cohort study presents a detailed examination of hepatitis C virus epidemiology in Lombardia (Italy) and was conducted within the ASST "Melegnano e della Martesana". The study involved comprehensive HCV screening of 3290 patients accessing the collection points and/or hospitalized in the facilities of the ASST from 20 May 2022 to 13 April 2023. Screening was conducted using serological assays. The prevalence of anti-HCV-positive patients (HCV-Ab) and then HCV-positive patients (RNA) was calculated. Chi-square tests examined the associations between continuous and categorical variables. Logistic regression was used to evaluate the influence of demographic and geographic variables as predictors of HCV positivity. The study revealed an overall HCV-Ab prevalence of 0.912% (CI (0.59-1.24%)) in the examined cohort, of whom 15.15% (two females and three males) were positive for HCV RNA. The prevalence of HCV RNA positivity was 0.152% (CI (0.05-0.35%)). Sex disparity was evident, with male patients exhibiting a higher prevalence compared to females, confirmed by logistic regression (0.0147 vs. 0.0061-OR = 2.44; CI (0.0059-0.0124)). Age stratification indicated an ascending trend in prevalence with age, peaking at 1.35% in individuals aged over 50. These findings underscore the critical need for targeted HCV screening, contributing valuable insights to the global epidemiology of HCV in the era of DAAs.
ABSTRACT
A cross sectional study was performed to determine the prevalence of hearing loss in individuals over age 65 years presenting to a medical centre in Lombardia (Italy). The aim was to assess the feasibility of performing a survey to evaluate the prevalence of hearing loss in the entire region. Audiometric testing was performed in each enrolled subject, to reveal losses in hearing levels at 250 to 8000 Hz; hearing levels were measured in decibels. Prevalences of mild, moderate, severe, and profound hearing impairment were found to be 39%, 17.4%, 2.9% and 0.6% respectively when using the WHO classification, and 59.9%, 25.6%, 2.9%, and 0.6% respectively when using the classification of the Bureau International d'Audiophonologie (BIAP).This study has shown that a relevant part of the study population is affected by hearing impairment and has served as a pilot study for a larger-scale study to be performed in the Lombardia region.
