ABSTRACT
BACKGROUND: Neonates are at high risk for nosocomial infections due to multidrug-resistant pathogens. The use of ß-lactamase inhibitors in combination with ß-lactam antibiotics broadens the antimicrobial spectrum. Cefoperazone/sulbactam is used in children but there are limited data on its usage in neonates. The purpose of the present study was therefore to evaluate the use of cefoperazone/sulbactam in the treatment of neonatal infections caused by multidrug-resistant pathogens. METHODS: The records of neonates who were hospitalized and who received cefoperazone/sulbactam were reviewed. RESULTS: There were 90 infants who received cefoperazone/sulbactam. A pathogen could be isolated in 41 (45.6%) of the infants. In total, 17.1% of isolated pathogens were resistant to cefoperazone/sulbactam. Side-effects were seen in four of the infants. Two infants had cholestasis, one infant had neutropenia and one had superinfection with candida. CONCLUSION: Cefoperazone/sulbactam can be used in the treatment of nosocomial infections caused by multidrug-resistant pathogens in neonates.
Subject(s)
Anti-Bacterial Agents/therapeutic use , Bacterial Infections/drug therapy , Cefoperazone/therapeutic use , Cross Infection/drug therapy , Sulbactam/therapeutic use , Drug Resistance, Multiple, Bacterial , Drug Therapy, Combination , Female , Humans , Infant, Newborn , Male , Microbial Sensitivity TestsABSTRACT
We present a fast NlogN time algorithm for computing quadratic-phase integrals. This three-parameter class of integrals models propagation in free space in the Fresnel approximation, passage through thin lenses, and propagation in quadratic graded-index media as well as any combination of any number of these and is therefore of importance in optics. By carefully managing the sampling rate, one need not choose N much larger than the space-bandwidth product of the signals, despite the highly oscillatory integral kernel. The only deviation from exactness arises from the approximation of a continuous Fourier transform with the discrete Fourier transform. Thus the algorithm computes quadratic-phase integrals with a performance similar to that of the fast-Fourier-transform algorithm in computing the Fourier transform, in terms of both speed and accuracy.