ABSTRACT
OBJECTIVES: The objectives of this study were to assess the effect of 8 weeks of moderate-intensity aerobic training on permeability inflammatory indicators of matrix metalloproteinases (MMPs) and specific tissue inhibitors of MMPs in female migraineurs. METHODS: Female migraineurs (n = 28, age 32 ± 6) were randomised into two groups: migraine with exercise training (EXE + Mig, n = 13) and migraine without exercise training (NON-EXE + Mig, n = 15). Matched healthy women were also recruited as a healthy control group (CON, n = 15). The EXE-Mig group performed 8 weeks of aerobic training. Pre and post intervention, serum matrix metalloproteinases (MMP-2 and 9) and specific tissue inhibitors of MMPs (TIMP-1 and 2) were measured. In addition, body composition indices and VO2max were determined. RESULTS: Exercise training reduced serum MMP-9 in female migraineurs with between-group changes and a time x group interaction (p < 0.05). In addition, exercise training reduced the serum MMP-9/TIMP-1 ratio in female migraineurs with between-group changes and time x group interaction (p < 0.05). However, no training-induced effect was observed in serum TIMP-1, TIMP-2, MMP-2 contents (p > 0.05) and MMP-2/TIMP-2 ratio (p > 0.05). Finally, exercise training reduced body fat content, WHR and BMI, and improved VO2max (p < 0.01). CONCLUSIONS: Our results demonstrated beneficial effects of aerobic exercise training on some circulatory inflammation factors (MMP9, MMP-9/TIMP-1) and some health indicators in female migraineurs, suggesting that such training can be employed as a non-pharmacological therapeutic method.
ABSTRACT
INTRODUCTION: Reperfusion and neuroprotection are 2 main treatment strategies exist for management of patients with ischemic stroke. This study aimed to assess the 3-month outcome of patients who underwent thrombolytic therapy following ischemic stroke. METHODS: In the present prospective cohort study, the 3-month outcome of patients (mortality, disability) with acute ischemic stroke admitted to neurology department an educational hospital, Kermanshah, Iran, from 2016 to 2019, who had received thrombolytic therapy was assessed. National Institute of Health Stroke Scale (NIHSS) and Modified Rankin Score (MRS) were used for measuring the degree of disability (on admission, at the time of discharge and 3 months after thrombolytic therapy). RESULTS: 217 patients with the mean age of 66.40 ± 13.37 (27 - 97) years were studied (55.3% male). There was no significant correlation between decrease in NIHSS score and age (p = 0.44), sex (p = 0.082), time interval between initiation of symptoms (p = 0.104), and blood pressure on admission (p = 0.156). However, patients with blood sugar lower than 144 had better 3-month outcome (p = 0.045). Additionally, there was no significant correlation between the rate of decrease in MRS score and age (p = 0.813), sex (p = 0.875), time interval between initiation of symptoms (p = 0.495), and blood pressure on admission (p = 0.264). However, patients with blood sugar lower than 144 had better 3-month outcome (p = 0.022). 47 (21.7%) patient died and 170 (78.3%) were discharged. Mean age of the patients who died (73.70 ± 11.85 versus 64.39 ± 13.09 years; p < 0.0001) and their NIHSS score on admission (13.22 ± 6.01 versus 11.28 ± 5.70; p = 0.045) were significantly higher. In other words, the odds of mortality was 3.19 times in patients over 60 years of age (95% confidence interval (CI): 1.18 - 8.62) and 1.83 times in patients with NIHSS score over 12 (95% CI: 0.92 - 3.61). CONCLUSION: There was no significant correlation between 3-month disabilities of stroke patients underwent thrombolytic therapy and age, sex, time from initiation of symptoms, or vital signs on admission. Patients with a blood sugar lower than 144 had better 3-month outcome.
ABSTRACT
Anthropometric indices that are indicators of nutrition status in children and adults can be affected by racial and geographic factors. The aim of present study was to investigate the relation of skull size and brain volume of Arak University of Medical Sciences students with their age, weight, height and body mass index. The present study was a cross-sectional study on 18-26 years old students of Arak University of Medical Sciences (150 female and 136 male) in 2009-2010 educational year. Sampling methods were probability and multi-stage methods which were performed using students' educational file and interviewing the subjects. Questions regarding anthropometric data (height, weight, age, body mass index and skull index) were included in the personal questionnaires. Data was analyzed and evaluated statistically using SPSS statistical software. Mean height was 177.27+/-6.41 cm in males and was 166.61+/-5.35 cm in females. Mean weight of males was 73.33+/-9.11 kg and mean weight of females was 55.55+/-7.28. Mean BMI was 23.20+/-2.43 and 21.27+/-2.69 in males and females, respectively. Mean skull index was 1.99+/-0.26 in males and 2.20+/-0.3 in females. Mentioned data were significantly different between males and females. Also mean age of females was less than males. Positive relations were found between skull volume and height, weight, age and BMI in both sexes and this relation is stronger regarding BMI. The present study, supporting the other studies in this field, confirms the relation between skull index and body mass index and indicates the effect of race. Considering the studied population which are students of Arak University of Medical Sciences and are from different regions of the country, similarities between results of this study and studies from Iran and studies conducted in a special region reveals that factor of race is affected by geographical factors.
Los índices antropométricos que son indicadores del estado nutricional en niños y adultos pueden ser afectados por factores raciales y geográficos. El objetivo del presente estudio fue investigar la relación entre el tamaño del cráneo y el volumen del cerebro con la edad, peso, talla e índice de masa corporal en los estudiantes de la Universidad de Ciencias Médicas de Arak. Se realizó un estudio transversal en estudiantes de 18-26 años de edad en la Universidad de Ciencias Médicas de Arak (150 mujeres y 136 hombres) en el año educativo 2009-2010. Los métodos de muestreo fueron probabilidad y métodos de etapas múltiples que se llevaron a cabo utilizando el archivo escolar de los estudiantes y entrevista a los sujetos. Preguntas sobre los datos antropométricos (talla, peso, edad, índice de masa corporal y el índice del cráneo) se incluyeron en los cuestionarios personales. Los datos fueron analizados y evaluados estadísticamente mediante paquete estadístico SPSS. La altura promedio fue 177,27 +/- 6,41 cm en hombres y 166,61 +/- 5,35 cm en las mujeres. La media de peso de los hombres fue 73,33 +/- 9,11 kg y 55,55 +/- 7,28 de las mujeres. El IMC promedio fue 23,20 +/- 2,43 y 21,27 +/- 2,69 en hombres y mujeres, respectivamente. La media del índice craneal fue de 1,99 +/- 0,26 en hombres y 2,20 +/- 0,3 en las mujeres. Los datos mencionados fueron significativamente diferentes entre hombres y mujeres. Además la media de edad de las mujeres fue menor que en los hombres. Las relaciones positivas se encontraron entre el volumen craneal y la altura, peso, edad y el IMC en ambos sexos y esta relación es más fuerte en relación con el IMC. El presente estudio, da apoyo a los otros estudios en este campo, confirma la relación entre el índice craneal y el IMC, y se indica el efecto de la raza. Teniendo en cuenta la población estudiada que son los estudiantes de la Universidad de Ciencias Médicas de Arak en diferentes regiones del país, las similitudes entre los resultados...
