ABSTRACT
Moderately elevated calcemia, increased urine calcium excretion, normal values of phosphate clearance and tubular phosphate resorption, elevated alkaline phosphatase were found in 50 patients with clinically confirmed thyrotoxicosis. With calcium loading, an essential calcium elevation in serum was determined as well as a delayed restoration to the norm of the latter, providing grounds to admit an insufficiency of hypocalcemia leading systems, thyrocalcitonine resp. The characteristic features of the X-ray changes observed are described, especially of osteoporosis. The bone changes were established to be more frequent among females (64% versus 204 among males). They increase in parallel with age advancing, during and severity of the disease. The special X-grams for fine analysis of bone structure according to Meema-Heunk enable the confirmation of intracortical striation in metacarpal bones and phalanges in 56.7 per cent of the examined.
Subject(s)
Bone Diseases/metabolism , Hyperthyroidism/metabolism , Adolescent , Adult , Age Factors , Bone Diseases/diagnostic imaging , Creatinine/metabolism , Female , Humans , Hyperthyroidism/diagnostic imaging , Male , Middle Aged , Phosphorus/metabolism , Potassium/metabolism , Radiography , Time FactorsABSTRACT
A case is reported of a patient, aged 20, with idiopathic hypoparathyroidism, manifested with the picture of epilepsy with a long treatment with antiepileptic remedies. Two years after the initiation of the antiepilertic treatment, severe skeleton disturbances occurred with manifested osteoporosis and multiple symmetric zones of bone reconstruction, hypocalcemia, hyperphosphatemia and elevated serum alkaline phosphatase. The disturbances of calcium and phosphorus level in blood are favourably affected by the application of relatively high vitamin D doses. The role of the long-term anticonvulsive treatment in the development of vitamin D resistant rickets and osteomalacia is discussed.
