Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 1 de 1
Filter
Add more filters









Database
Language
Publication year range
1.
Defibrinogenation Ameliorates Retinal Microgliosis and Inflammation in A CX3CR1-Independent Manner.
Sarker, Borna; Cardona, Sandra M; Church, Kaira A; Vanegas, Difernando; Velazquez, Priscila; Rorex, Colin; Rodriguez, Derek; Mendiola, Andrew S; Kern, Timothy S; Domingo, Nadia D; Stephens, Robin; Muzzio, Isabel A; Cardona, Astrid E.
ASN Neuro ; 14: 17590914221131446, 2022.
Article in English | MEDLINE | ID: mdl-36221892

ABSTRACT

SUMMARY STATEMENT: Diabetic human and murine retinas revealed pronounced microglial morphological activation and vascular abnormalities associated with inflammation. Pharmacological fibrinogen depletion using ancrod dampened microglial morphology alterations, resolved fibrinogen accumulation, rescued axonal integrity, and reduced inflammation in the diabetic murine retina.


Subject(s)
Ancrod , Retina , Animals , CX3C Chemokine Receptor 1/genetics , Fibrinogen , Humans , Inflammation/drug therapy , Mice , Microglia , Retina/physiology
SEND TO:
Email
Export
Print
RSS
XML
SELECTION OF CITATIONS
SEARCH DETAIL