ABSTRACT
The enhancement of the sum of phospholipids in seizure period was observed during initially generalized corazol seizure in white rats' cerebral cortex. This sum fell in an hour after epileptic fit. It is noted that the maintenance of lysophosphatidylcholines and phosphatidylserines enhanced during the fit, and the maintenance of phosphatidylcholines and phosphatidylethanolamines fell either in cerebral cortex, or in cerebellum. At the same time the enhancement of the mixed fraction of sphingomyelin and phosphatidylinositide level and cardiolipins-1 in the cerebral cortex was observed. The maintenance of the latter in cerebellum fell during an hour after the attack. The quantity of cardiolipins-2 in cerebellum enhanced during the attack. It is suggested that the effect of corazol seizure leads to the enhancement of lisoforms at the expense of the intensification of disintegration of other fractions of lisoforms.
Subject(s)
Cerebellum/metabolism , Cerebral Cortex/metabolism , Disease Models, Animal , Epilepsy/metabolism , Phospholipids/metabolism , Animals , Cerebellum/chemistry , Cerebral Cortex/chemistry , Chromatography, Thin Layer/methods , Epilepsy/chemically induced , Pentylenetetrazole , Phospholipids/chemistry , RatsABSTRACT
Effect of alloxan on activity of acetylphosphatase, alkaline and acid phosphatases, phenylpyrophosphatase was studied in vitro. Alloxan at concentrations 100 microM-10 mM inhibited acid phosphatase and especially alkaline phosphatase. Reducing agents (pyrocatechol, hydroquinone, ascorbic acid), which are easily converted into corresponding oxidized forms, at concentrations 100 microM-1.0 mM activated alkaline phosphatase in rat kidney and small intestine.
Subject(s)
Acid Phosphatase/antagonists & inhibitors , Alkaline Phosphatase/antagonists & inhibitors , Alloxan/pharmacology , Phosphoric Monoester Hydrolases/antagonists & inhibitors , Phosphorus/metabolism , Animals , Chickens , Diabetes Mellitus, Experimental/enzymology , In Vitro Techniques , Phosphorylation , Rats , Swine , Tissue DistributionABSTRACT
Electrical stimulation of the raphe nuclei and locus coeruleus induces inhibition of the penicillin-induced seizure activity. Adrenoblocking agents facilitate the effects of raphe nuclei on the seizure activity.
