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1.
Eur J Gynaecol Oncol ; 37(5): 671-673, 2016.
Article in English | MEDLINE | ID: mdl-29787008

ABSTRACT

PURPOSE OF INVESTIGATION: To evaluate the feasibility, safety, and effectiveness of laparoendoscopic single site surgery (LESS) for the assessment of peritoneal carcinomatosis resectability in patients with advanced stage ovarian cancer (AOC). MATERIALS AND METHODS: The authors retrospectively reviewed the medical records of patients affected by advanced stage ovarian cancer who underwent LESS for operative work-up. A standard cytoreductive laparotomy surgery (CRS) was performed. RESULTS: Fifty-two women affected by AOC underwent LESS for operative work-up. The peritoneal cancer score was completed in 49 (94%) patients by use of LESS; 34/37 (92%) patients considered with a resectable disease were effectively optimally debulked and 15/52 (28%) patients considered with an unresectable disease received before neoadjuvant chemotherapy (NACT) and then underwent surgery. CONCLUSION: LESS is feasible, safe, and is an alternative minimally invasive procedure to assess the resectability of AOC patients.


Subject(s)
Laparoscopy , Ovarian Neoplasms/surgery , Peritoneal Neoplasms/surgery , Aged , Female , Humans , Middle Aged , Neoplasm Staging , Ovarian Neoplasms/pathology , Retrospective Studies
2.
Eur J Gynaecol Oncol ; 37(5): 685-688, 2016.
Article in English | MEDLINE | ID: mdl-29787011

ABSTRACT

PURPOSE OF INVESTIGATION: The aim of this prospective study was the evaluation of low-grade intraepithelial lesion (LSIL) lesions evolvement in woman with evidence of high risk HPV infection and p 16 4a negative expression. MATERIALS AND METHODS: 150 women with cytological diagnosis of LSIL were selected to be underwent to three years of follow-up consisting in smear test, colposcopy, and protein p16I4a investigation every six months and HPV-test every 12 months. RESULT: Final follow-up showed 45 cases of spontaneous lesion regression and 42 cases of persistence with absence of protein p164NK4a in all of them. There were three cases of disease progression to CIN2, two at 18-month follow-up and one at last follow-up. Disease progression was characterized of p16NK4a expression. CONCLUSION: p16l4a should help to identify which LSIL cases are inclined to the progression of the disease and focalize which patients are eligible for specific treatment.


Subject(s)
Biomarkers, Tumor/analysis , Cyclin-Dependent Kinase Inhibitor p16/analysis , Squamous Intraepithelial Lesions of the Cervix/diagnosis , Adult , DNA, Viral/analysis , Disease Progression , Female , Humans , Middle Aged , Papillomaviridae/isolation & purification , Squamous Intraepithelial Lesions of the Cervix/virology , Uterine Cervical Neoplasms/diagnosis , Uterine Cervical Dysplasia/diagnosis
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