ABSTRACT
Preclinical studies have attributed 3,3',5-triiodo-L-thyronine (T3) a direct negative effect on tumor progression, as well as chemosensitizing, differentiating and immunomodulatory properties. On the other hand, L-thyroxine (T4), via a thyroid hormone receptor on plasma membrane integrin αvß3, promotes solid tumor growth and neoangiogenesis, therefore lowering endogenous T4 reduces tumor growth rate. We present the case of two patients with metastatic triple negative breast cancer and metastatic pancreatic cancer respectively, who benefit of the sole treatment with antithyroid drugs and exogenous administration of T3 (liothyronine). In these cases tumor growth was accompanied by T3 depletion in plasma, which may represent a novel marker for progression.
Subject(s)
Biomarkers, Tumor/blood , Pancreatic Neoplasms/drug therapy , Triiodothyronine/administration & dosage , Triiodothyronine/blood , Triple Negative Breast Neoplasms/drug therapy , Aged , Aged, 80 and over , Female , Humans , Neoplasm Metastasis , Pancreatic Neoplasms/blood , Pancreatic Neoplasms/pathology , Triple Negative Breast Neoplasms/blood , Triple Negative Breast Neoplasms/pathologyABSTRACT
We report a case of small bowel obstruction secondary to internal hernia through a defect in the broad ligament diagnosed by MDCT and confirmed at surgery. The CT findings that allow the diagnosis of this very rare cause of SBO are presented here.
Subject(s)
Broad Ligament/diagnostic imaging , Hernia, Abdominal/complications , Hernia, Abdominal/diagnostic imaging , Intestinal Obstruction/etiology , Multidetector Computed Tomography , Aged , Female , Humans , Hysterosalpingography , Preoperative PeriodABSTRACT
Presentamos los hallazgos por tomografia computarizada (TC) de tres casos de rotura intraperitoneal de teratomas maduros quísticos de ovario. Los hallazgos radiológicos en la fase aguda incluyen la presencia de líquido intraabdominal, infiltración de la grasa mesentérica y masa pélvica con contenido cálcico y graso en su interior. Los hallazgos en la fase crónica incluyen infiltración de la grasa peritoneal con aumento de tamaño de los ganglios adyacentes, debido a una reacción inflamatoria crónica por cuerpo extraño demostrable histológicamente. Se han revisado los diagnósticos diferenciales de la rotura intraperitoneal del teratoma maduro agudo y crónico (AU)
