ABSTRACT
30 piperidine ethyl esters of alkoxyphenylcarbamic acids with local anaesthetic activity to be distinguished by the type of substitution of the alkoxy groups were investigated under various conditions (temperature, volume of the stationary phase) using GLC. The retention data were determined by means of usual methods and converted into Kovats-indices using a new simplified procedure. These indices were correlated with data representing local anaesthetic activity and toxicity.
Subject(s)
Anesthetics, Local/chemical synthesis , Carbamates/chemical synthesis , Piperidines/chemical synthesis , Anesthetics, Local/analysis , Anesthetics, Local/toxicity , Animals , Carbamates/analysis , Carbamates/pharmacology , Carbamates/toxicity , Chromatography, Gas , Lethal Dose 50 , Mice , Piperidines/analysis , Piperidines/pharmacology , Piperidines/toxicity , Structure-Activity RelationshipSubject(s)
Benzothiepins/analysis , Central Nervous System Agents/analysis , Piperidines/analysis , Adsorption , Animals , Benzothiepins/chemical synthesis , Central Nervous System Agents/chemical synthesis , Central Nervous System Agents/pharmacology , Chemical Phenomena , Chemistry, Physical , Chromatography , Mice , Piperidines/chemical synthesis , Structure-Activity RelationshipABSTRACT
The RF-values of 19 fungicidal pyrimidine derivatives were determined by means of thin-layer chromatography (aluminium oxide layers) in some solvent systems and the relating parameters of adsorption chromatography were calculated. Furthermore the retention times of HPLC were determined. Both of the parameters were correlated with experimentally determined biological values.
