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Chem Pharm Bull (Tokyo) ; 72(1): 98-101, 2024.
Article in English | MEDLINE | ID: mdl-38233138

ABSTRACT

A novel tricyclic polyketide, curvulanone (1), was isolated from the marine-derived fungus Curvularia aeria. The structure of 1 was determined by NMR and single-crystal X-ray crystallography. 1 had a cyclopentabenzopyranone with 3-acetic acid structure that is rarely found in natural compounds. Monoamine oxidase and sirtuin 1 inhibitory test was exhibited and 1 showed their inhibitory activity.


Subject(s)
Polyketides , Polyketides/pharmacology , Polyketides/chemistry , Fungi , Curvularia , Molecular Structure
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