ABSTRACT
The aim of the study was to evaluate dynamics of selected acute phase proteins in serum and cerebrospinal fluid (CSF) in children with viral meningitis and to assess diagnostic power of protein determination for detection and treatment monitoring. 51 children with viral meningitis caused by ECHO 30 virus were included in the study group. Concentration of C-reactive protein (CRP), alpha 1-antitrypsin (AAT), alpha1-acid glycoprotein (AAG), alpha2-haptoglobin (HPT) and C3 complement fragment were determined in serum and CSF at entry and at day 14 after admittance to hospital. Control group for serum determination consisted in 30 healthy children (Group K1) and control group for CSF determination consisted in 19 hospitalized children in whom the diagnosis of meningitis was not confirmed (group K2). The greatest rise of acute phase proteins concentration was observed in children in case of HPT, AAG and C3 complement when determined in serum. Meningitis in children that was caused by ECHO 30 virus produces slight acute phase reaction that is more evident in serum than in CSF. It is confirmed by remarkable increase of AAG, HPT, C3 complement in serum and HPT in CSF either at entry or at the day 14. The determination of AAG, HPT and C3 complement in serum have diagnostic power that is strong enough to meningitis diagnostics and monitoring of treatment.
Subject(s)
Acute-Phase Proteins/metabolism , Acute-Phase Reaction/virology , Meningitis, Viral/blood , Meningitis, Viral/cerebrospinal fluid , Acute-Phase Proteins/cerebrospinal fluid , Adolescent , C-Reactive Protein/metabolism , Case-Control Studies , Child , Child, Preschool , Complement C3/metabolism , Female , Haptoglobins/metabolism , Humans , Male , Meningitis, Viral/epidemiology , Orosomucoid/metabolism , Poland/epidemiology , Statistics, Nonparametric , Time Factors , alpha 1-Antitrypsin/metabolismABSTRACT
Clinical picture of Borrelia burgdorferi infection has been presented in 45 children, aged 2-16 years from Lódz region. The analysis showed significant domination of cases with affected central and peripheral nervous system (44.4%) and rather unspecific symptoms such as: fever (20%) or headache (13.3%). Peripheral cranial nerves paralysis and symptoms of cerebrospinal meningitis dominated among children with neuroborreliosis. Unlike descriptions concerning adults, majority of the observed symptoms were changes characteristic for I and II stage of the disease. Dermatosis was found only in 1 child and symptoms of arthritis in 2 of them. Contact with tick was stated in 52% of the analysed children. Incidence of the disease occurred throughout the whole year, more frequently in summer and autumn months.
