ABSTRACT
No disponible
Subject(s)
Male , Female , Child, Preschool , Child , Humans , Mucopolysaccharidosis I/drug therapy , Enzyme Reactivators/therapeutic use , Enzymes/therapeutic useSubject(s)
Asbestos/adverse effects , Asbestosis , Environmental Exposure/adverse effects , Lung Diseases/etiology , Lung Neoplasms/etiology , Mesothelioma/etiology , Occupational Exposure/adverse effects , Pleural Diseases/etiology , Pleural Neoplasms/etiology , Asbestosis/diagnosis , Asbestosis/diagnostic imaging , Asbestosis/epidemiology , Bronchoalveolar Lavage Fluid , Bronchoscopy , Data Interpretation, Statistical , Diagnosis, Differential , Female , Humans , Incidence , Lung Neoplasms/diagnosis , Lung Neoplasms/surgery , Male , Mesothelioma/diagnosis , Mesothelioma/surgery , Odds Ratio , Pleural Neoplasms/diagnosis , Pleural Neoplasms/surgery , Prevalence , Pulmonary Atelectasis/etiology , Pulmonary Fibrosis/diagnosis , Radiography, Thoracic , Risk Factors , Sex Factors , SpainSubject(s)
Asthma/drug therapy , Bronchodilator Agents/therapeutic use , Budesonide/therapeutic use , Lung Diseases/microbiology , Mycobacterium Infections/complications , Mycobacterium fortuitum/isolation & purification , Adult , Anti-Bacterial Agents/therapeutic use , Diagnosis, Differential , Humans , Lung Diseases/diagnosis , Lung Diseases/drug therapy , Male , Mycobacterium Infections/drug therapy , Tomography, X-Ray ComputedABSTRACT
No disponible
Subject(s)
Male , Humans , Adult , Mycobacterium fortuitum , Budesonide , Bronchodilator Agents , Asthma , Anti-Bacterial Agents , Diagnosis, Differential , Tomography, X-Ray Computed , Mycobacterium Infections , Lung DiseasesABSTRACT
BACKGROUND AND OBJECTIVES: Plasma exchange with fresh-frozen plasma (FFP) is the treatment of choice in thrombotic thrombocytopenic purpura (TTP). Methylene blue-photoinactivated plasma (MBPIP) has been proposed as a safer alternative to FFP, but its effectiveness in the treatment of TTP is not well established. The purpose of this study was to investigate whether MBPIP is as effective as FFP in the treatment of TTP by plasma exchange. MATERIALS AND METHODS: A retrospective analysis was carried out of 56 TTP episodes, occurring between 1990 and 2003, which had been treated by plasma exchange. MBPIP was used for fluid replacement in 27 episodes and FFP in 29. The effect of plasma (MBPIP or FFP) on treatment outcomes was analysed by multivariate logistic regression. RESULTS: Compared to patients treated with FFP, those receiving MBPIP had an increased risk of dying from progressive TTP [adjusted odds ratio (OR) = 31; 95% confidence interval (CI): 1.2 to > 100], a greater number of recurrences while on plasma exchange therapy (OR = 4.6; 95% CI: 1.2-17), and a lower probability of attaining a sustained remission within 9 days of starting plasma exchange (OR = 5.2; 95% CI: 1.3-20). CONCLUSIONS: MBPIP seems to be less effective than FFP in the treatment of TTP. It is therefore prudent to avoid MBPIP until therapeutic equivalency to FFP has been established by randomized, controlled trials.
Subject(s)
Methylene Blue/radiation effects , Plasma Exchange/methods , Plasma/drug effects , Purpura, Thrombotic Thrombocytopenic/therapy , Virus Inactivation , Adult , Aged , Aged, 80 and over , Disease Progression , Female , Humans , Male , Middle Aged , Photochemistry , Plasma/radiation effects , Purpura, Thrombotic Thrombocytopenic/mortality , Recurrence , Remission Induction , Retrospective Studies , Survival Analysis , Treatment OutcomeABSTRACT
We report herein a 38-year-old male patient with Fanconi anemia but with few phenotypic manifestations--short stature, sterility, and hypoplasic anemia with several years of evolution-who developed a myelodysplastic syndrome (MDS). Bone marrow karyotype showed long arm triplication of chromosome 1 (q12-21q31-q32), and two markers add(11)(p15) and add(21)(q22) which had extra material of chromosome 3 besides the normal chromosome 3 pair. Peripheral blood showed chromosome instability; SCE was normal. Both the patient and his family showed a high prevalence of malignant diseases. 1q duplication and, in a few cases, triplication of 1q has been related to Fanconi anemia, being of unknown significance.
Subject(s)
Chromosome Aberrations , Chromosome Disorders , Chromosomes, Human, Pair 1/genetics , Fanconi Anemia/genetics , Adult , Bone Marrow/pathology , Cytogenetic Analysis , Humans , Male , Sister Chromatid ExchangeSubject(s)
Fungemia/microbiology , Leukemia, Myeloid/complications , Neutropenia/complications , Opportunistic Infections/microbiology , Pharyngitis/microbiology , Yeasts/isolation & purification , Acute Disease , Adult , Antifungal Agents/therapeutic use , Fungemia/drug therapy , Fungemia/etiology , Humans , Immunocompromised Host , Male , Opportunistic Infections/drug therapy , Opportunistic Infections/etiology , Pharyngitis/drug therapy , Pharyngitis/etiologyABSTRACT
No disponible
Subject(s)
Adult , Male , Humans , Pneumonia, Bacterial , Coxiella burnetii/isolation & purification , Atypical Bacterial Forms , Q FeverSubject(s)
Brain Neoplasms/etiology , Intestinal Neoplasms/etiology , Kidney Transplantation/adverse effects , Lymphoma, Non-Hodgkin/etiology , Lymphoma, T-Cell/etiology , Brain Neoplasms/pathology , Fatal Outcome , Humans , Intestinal Neoplasms/pathology , Kidney Failure, Chronic/surgery , Lymphoma, Non-Hodgkin/pathology , Lymphoma, T-Cell/pathology , Male , Middle AgedABSTRACT
Mesenteric venous thrombosis has not been reported after an appendicectomy in the pediatric literature. We report on a special and very unusual complication in a girl who presented mesenteric venous thrombosis (MVT) following an appendicectomy for gangrenous appendicitis. The early diagnosis of this entity is vital in order to start the anticoagulation treatment which could allow preservation of bowel viability. The therapy should be continued for a long time to decrease the risk of relapse.
Subject(s)
Appendectomy/adverse effects , Appendicitis/complications , Mesenteric Vascular Occlusion/etiology , Venous Thrombosis/etiology , Appendicitis/surgery , Child , Female , Humans , Mesenteric VeinsABSTRACT
Mesenteric venous thrombosis (MVT) after appendicectomy has not been reported in the pediatric literature. This complication is associated with significant morbidity and mortality rates in adults. The report of this case attempts to analyze the features found in an appendicectomized child documented by radiological examination and surgery before and after starting heparin therapy. Anticoagulation treatment should be started as soon as possible and continued for a long time to decrease the risk of relapse.
Subject(s)
Appendectomy , Mesenteric Veins , Postoperative Complications , Venous Thrombosis/etiology , Child , Female , Humans , Venous Thrombosis/diagnosis , Venous Thrombosis/surgeryABSTRACT
Most therapies for elderly patients with myelodysplastic syndromes offer few short responses and little improvement in survival. We describe two patients who, after several cycles of low dose cytosine arabinoside and GM-CSF, achieved and maintained complete remission and became transfusion independent. Previous chromosomal abnormalities also disappeared and karyotype remains normal.
Subject(s)
Anemia, Refractory/therapy , Anemia, Sideroblastic/therapy , Chromosome Aberrations , Cytarabine/therapeutic use , Granulocyte-Macrophage Colony-Stimulating Factor/therapeutic use , Immunologic Factors/therapeutic use , Aged , Anemia, Refractory/drug therapy , Anemia, Refractory/genetics , Anemia, Refractory/pathology , Anemia, Sideroblastic/drug therapy , Anemia, Sideroblastic/genetics , Anemia, Sideroblastic/pathology , Cytarabine/administration & dosage , Female , HumansABSTRACT
Granulocytic sarcoma (GS) is a rare extramedullary tumor composed of myeloblasts and other granulocytic precursors. GS is mostly associated with myeloproliferative disorders, myelodysplastic syndromes and acute myeloid leukaemia. These tumors arise in the absence of leukaemia, at its initial diagnosis or at the time of recurrence. The most common sites of involvement are bone, skin, soft tissue and lymph node. Reports of GS in testis are very rare. We report an unusual case of GS in a patient with megakaryoblastic leukaemia arising in the left testis after four months in complete remission attained with low doses of Ara-C and granulomonocytic stimulating factor.
Subject(s)
Leukemia, Megakaryoblastic, Acute/pathology , Testicular Neoplasms/pathology , Aged , Antimetabolites, Antineoplastic/therapeutic use , Cytarabine/therapeutic use , Fatal Outcome , Granulocyte-Macrophage Colony-Stimulating Factor/therapeutic use , Humans , Leukemia, Megakaryoblastic, Acute/drug therapy , Male , RecurrenceSubject(s)
Hodgkin Disease/diagnosis , Lung Neoplasms/diagnosis , Adult , Diagnosis, Differential , Female , HumansABSTRACT
Trousseau's syndrome includes a wide range of coagulation disorders, migratory thrombotic phenomena being the main associated entities. Treatment is difficult and venous gangrene constitutes a rare but deadly final stage that is particularly painful for the patient. The outlook after treatment is poor.
