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Angiology ; 42(4): 323-30, 1991 Apr.
Article in English | MEDLINE | ID: mdl-1826589

ABSTRACT

The effects of n-3 fatty-acid supplementation on serum lipids, platelet aggregation, and the development of atherosclerotic lesions were studied in the cholesterol-fed rabbit. Serum total cholesterol and LDL cholesterol values were significantly reduced in comparison with those of the nonsupplemented cholesterol-fed group (p less than 0.005, p less than 0.0025, respectively), though still higher than those of the control group (p less than 0.0025, p less than 0.0125 respectively). Platelet aggregation was reduced below that of the cholesterol-fed and the control levels (p less than 0.0005, p less than 0.0025, respectively). The endothelial injury encountered in cholesterol-fed rabbits was inhibited in the supplemented group. It is concluded that n-3 fatty acids suppress atherogenesis in this animal model by interfering with platelet aggregation and lipid metabolism.


Subject(s)
Arteriosclerosis/prevention & control , Docosahexaenoic Acids/pharmacology , Eicosapentaenoic Acid/pharmacology , Lipids/blood , Platelet Aggregation Inhibitors/pharmacology , Platelet Aggregation/drug effects , Animals , Arteries/drug effects , Arteriosclerosis/blood , Cholesterol/blood , Diet, Atherogenic , Endothelium, Vascular/drug effects , Male , Rabbits
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