1.
Org Lett
; 20(9): 2787-2791, 2018 05 04.
Article
in English
| MEDLINE
| ID: mdl-29697260
ABSTRACT
A Lewis acid catalyzed regioselective C-C bond is constructed through ß-addition of deconjugated butenolides with p-quinone methides in a 1,6-conjugate addition manner. Interestingly, Lewis acid catalyzed vinylogous Mukaiyama-Michael reaction of silyloxyfurans with p-QMs proceeds selectively through the α or γ position exclusively. The reaction is mild with broad substrate scope, thus allowing easy access to a wide range of bis-arylated α-/ß-/γ-substituted butenolides.