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Drug Dev Res
; 81(3): 283-294, 2020 05.
Article
in English
| MEDLINE
| ID: mdl-31693218
ABSTRACT
Two multitarget hybrids, derived from an aza-analogue of CGP37157, a mitochondrial Na+ /Ca2+ exchanger antagonist, and lipoic acid were designed in order to combine in a single molecule the antioxidant and Nrf2 induction properties of lipoic acid and the neuroprotective activity of CGP37157. The hybrid derivatives showed Nrf2 induction and radical scavenging properties, leading to a good neuroprotective profile against oxidative stress, together with an interesting antineuroinflammatory activity. The results obtained show differences in activity depending on the configuration of the chiral center of LA.
Subject(s)
Antioxidants/pharmacology , Neuroprotective Agents/pharmacology , Thiazepines/pharmacology , Thioctic Acid/pharmacology , Animals , Anti-Inflammatory Agents/chemistry , Anti-Inflammatory Agents/pharmacology , Antioxidants/chemistry , Cell Line , Humans , Inflammation/drug therapy , Inflammation/pathology , Male , NF-E2-Related Factor 2/metabolism , Neuroprotective Agents/chemistry , Oxidative Stress/drug effects , Rats , Rats, Sprague-Dawley , Thiazepines/chemistry , Thioctic Acid/chemistry
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