ABSTRACT
Histiocytosis refers to a diverse collection of disorders unified by a proliferation and accumulation of histiocytes into a variety of organs. The following review article will discuss and briefly describe the clinical and histological findings of some of the more common histiocytic disorders. The article is divided into sections according to the current classification system and prevalence of the condition.
Subject(s)
Histiocytosis , Dendritic Cells , Histiocytosis/diagnosis , Histiocytosis/therapy , Humans , Macrophages , Monocytes , PrognosisABSTRACT
We present a unique case of an infant with acute monocytic leukaemia who presented at birth with multiple rubbery, erythematous to violaceous subcutaneous nodules secondary to leukaemia cutis. As these infiltrates regressed with chemotherapy, numerous white to yellow linear confluent papules appeared in a scratch-like pattern. These lesions were widely disseminated but were concentrated across her face, trunk and extremities with relative sparing of the napkin area and back. We propose that these lesions represent a form of dystrophic calcinosis cutis that occurred secondary to koebnerization in an infant with congenital leukaemia cutis.
Subject(s)
Calcinosis/pathology , Leukemia, Monocytic, Acute/congenital , Leukemia/pathology , Leukemic Infiltration/pathology , Skin Diseases/pathology , Calcinosis/complications , Female , Humans , Infant, Newborn , Leukemia/complications , Leukemia, Monocytic, Acute/complications , Leukemic Infiltration/complications , Skin Diseases/complicationsABSTRACT
Deficits at the earliest stages of information processing are among the most consistent abnormalities found in schizophrenics. To better understand the deficit, the present study indirectly evaluated the functional status of two visual channels, transient and sustained, which have been implicated in early information processing. A forced-choice, two-pulse detection task was used to determine the duration that subjects required to detect a blank interval (ISI) separating a two pulse grating vs. a single pulse grating. Threshold ISI was used as the index of visible persistence. Four groups of subjects participated in the study: schizophrenics, schizoaffectives, major depressives, and normal controls. The results of the ANOVA showed a significant main effect for diagnosis, position, and spatial frequency, as well as a significant effect for diagnosis x position and diagnosis x spatial frequency. The results are discussed in terms of the differential response and retinal distribution of each channel.