[C-2 basically substituted thiazoles with H2-antagonistic action. 21. H2-antihistaminics]. / C-2 Basisch substituierte Thiazole mit H2-antagonistischer Wirkung 21. Mitt.: H2-Antihistaminika.

In studies on structure-activity relationships of histamine H2-receptor antagonists, C-2 basically substituted thiazoles were prepared and tested for their H2-antihistaminic activity on the isolated guinea-pig atrium and on the histamine stimulated acid secretion of the anaesthetized rat. As a basic substituent the dimethylaminomethyl group is especially suitable, while cyclic guanidines lead to lower H2-antagonistic activity.

[Action of partially cyclic and ring methylated nikethamide analogs. Structure-activity relationships of analeptics of the nicethamide type]. / Zur Wirkung partiell zyklischer und kernmethylierter Nicethamid-Analoga. 2. Mitteilung: Stuktur-Wirkungs-Beziehungen bei Analeptika vom Typ des Nicethamids

Investigation concerning the respiratory-analeptical effect of partially cyclic and ring methylated nicethamide analogues are reported. The respiration of the rabbit determined by the mask method, served as pharmacological model.

[Vaccination of children against influenza]. / Grippeschutzimpfung bei Kindern

In 19 children of 1-7 years of age hemagglutination inhibiting antibodies were measured before and after vaccination against influenza. Before vaccination the serum titers have been markedly lower than in adults. A single vaccination with Alorbat, a vaccine of representative strains of influenza virus inactivated and adsorbed to aluminumoxide, was followed by the same rise of titer as in adults. Therefore with this vaccine a single vaccination is effective in children, and a booster 4 weeks later, as recommended otherwise, is not necessary.