1.
Org Lett
; 13(19): 5044-7, 2011 Oct 07.
Article
in English
| MEDLINE
| ID: mdl-21888335
ABSTRACT
Treatment of alk-2-ynyl derivatives of enantiopure phenylglycidol with NaN(3) triggers a cascade reaction consisting of stereospecific and regioselective epoxide ring opening followed by intramolecular azide-alkyne cycloaddition under strictly metal-free conditions. This simple one-pot procedure allows a fast buildup of molecular complexity, generating a wide array of triazolooxazepinols, triazolodiazepinols, and triazolothiazepinols.
2.
Org Lett
; 11(10): 2193-6, 2009 May 21.
Article
in English
| MEDLINE
| ID: mdl-19419215
ABSTRACT
The Lewis acid-mediated addition of titanium enolates from 1 to dimethyl ketals of aliphatic methyl ketones followed by removal of the chiral auxiliary furnishes enantiomerically pure derivatives containing a tertiary methyl ether and a contiguous stereocenter in a straightforward manner.