ABSTRACT
UNLABELLED: We evaluated the effectiveness of oral misoprostol for outpatient cervical ripening and labor induction in prolonged pregnancies. We performed a randomized, double-blind, placebo-controlled study of women at 40 to 42 weeks' gestation with well-dated pregnancies, singleton gestations, Bishop scores less than 6, vertex presentations, and intact membranes. Subjects received either oral misoprostol 100 microg or placebo daily for 3 days unless the subject developed significant cervical change or began labor spontaneously. Study drug was repeated every 24 hours for a maximum of three doses if subjects did not develop significant cervical change or enter labor. Induction of labor was not allowed while the subject was enrolled in the study. Forty-three subjects were randomized to receive misoprostol and 44 randomized to receive placebo. A significant difference was noted in reduction of time from study entry to both active phase (p < 0.001) and delivery (p < 0.001) in the misoprostol group. Fewer women remained undelivered after the 72-hour study period in the misoprostol group. There were no differences in route of delivery or neonatal outcomes between groups. CONCLUSION: Daily administration of oral misoprostol over 3 days to women with prolonged pregnancies shortened time intervals from dosing to entry into active labor and delivery compared with placebo.
Subject(s)
Abortifacient Agents, Nonsteroidal/therapeutic use , Cervical Ripening/drug effects , Misoprostol/therapeutic use , Pregnancy Outcome , Pregnancy, Prolonged/drug therapy , Adult , Ambulatory Care/methods , Chi-Square Distribution , Dose-Response Relationship, Drug , Drug Administration Schedule , Female , Fetal Monitoring , Follow-Up Studies , Humans , Labor, Induced/methods , Pilot Projects , Pregnancy , Probability , Reference Values , Risk Assessment , Treatment OutcomeABSTRACT
OBJECTIVE: The purpose of this study was to assess the correlation and agreement between transvagi-nal and transabdominal cervical length measurement after bladder emptying as well as the feasibility of transabdominal sonography in cervical length screening. METHODS: This was a prospective cohort study involving 287 participants (14-34 weeks' gestation) from January to December 2003. After voiding, transabdominal and transvaginal cervical length measurements were obtained. The optimal trans-abdominal technique was established during an unblinded series of transabdominal and transvaginal cervical length measurements (n = 96). The same measurements were obtained in 191 participants under a blinded 2-sonographer protocol. The transabdominal cervical length cutoff to ensure 100% sensitivity in detecting a short cervix (Subject(s)
Abdomen/diagnostic imaging
, Cervix Uteri/diagnostic imaging
, Image Enhancement/methods
, Ultrasonography, Prenatal/methods
, Urinary Bladder/diagnostic imaging
, Urination
, Adult
, Female
, Humans
, Pregnancy
, Reproducibility of Results
, Sensitivity and Specificity