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1.
Br J Ophthalmol ; 99(10): 1401-4, 2015 Oct.
Article in English | MEDLINE | ID: mdl-25868792

ABSTRACT

BACKGROUND: Lyme neuroborreliosis (LNB) designates central nervous system involvement caused by the tick-borne spirochaete Borrelia burgdorferi (Bb). The present study describes a spectrum of acquired ocular motor disorders in children with LNB. METHODS: Six paediatric patients (age 3-15 years) with ocular motor symptoms as first manifestations of LNB evaluated by a paediatrician and ophthalmologist are presented. Diagnosis was based on new onset ocular motor disturbances and detection of cerebrospinal fluid (CSF) pleocytosis and intrathecal synthesis of Bb IgM and/or IgG antibodies by lumbar puncture. The children were evaluated before and after antibiotic treatment with a follow-up time of 1-7 months. Videos were obtained both pre and post treatment in four patients. RESULTS: Two children presented with acquired nystagmus, one with combined nystagmus and partial sixth nerve palsy, one with partial sixth nerve palsy, one with ptosis and one with Adie's pupil. Five of the patients presented with severe fatigue, malaise, nausea, headache and fever. Four had recognised a tick bite recently, and two developed erythema migrans. Intrathecal synthesis of IgM and/or IgG antibodies specific for Bb was positive in all children, and five showed CSF pleocytosis. Cerebral MRI or CT of the brain were normal. Treatment with intravenous or oral antibiotics produced rapid clinical improvement in five of the six children. CONCLUSIONS: LNB can present as acute ocular motor disorders in conjunction with fatigue and other clinical manifestations. In endemic areas, children with unexplained, acquired ocular motor abnormalities should be evaluated for LNB, a treatable medical condition.


Subject(s)
Anti-Bacterial Agents/administration & dosage , Antibodies, Bacterial/immunology , Borrelia burgdorferi/immunology , Eye Infections, Bacterial/complications , Eye Movements/physiology , Lyme Neuroborreliosis/complications , Ocular Motility Disorders/etiology , Acute Disease , Administration, Oral , Adolescent , Borrelia burgdorferi/isolation & purification , Child , Child, Preschool , Denmark/epidemiology , Enzyme-Linked Immunosorbent Assay , Eye Infections, Bacterial/epidemiology , Eye Infections, Bacterial/therapy , Female , Humans , Incidence , Injections, Intravenous , Lyme Neuroborreliosis/drug therapy , Lyme Neuroborreliosis/epidemiology , Male , Ocular Motility Disorders/drug therapy , Ocular Motility Disorders/epidemiology , Retrospective Studies
2.
Ugeskr Laeger ; 161(51): 7069-70, 1999 Dec 20.
Article in Danish | MEDLINE | ID: mdl-10647300

ABSTRACT

Two patients who sustained serious facial, cranial and eye trauma secondary to recreational fireworks injuries are reported. Initial assessment included axial and coronary computerized tomography, control of haemorrhage, debridement of wound and brain, and in one patient bilateral excenteration of the globe. Both patients suffered from intracranial haemorrhage, but both recovered without severe neurological sequelae.


Subject(s)
Blast Injuries/etiology , Craniocerebral Trauma/etiology , Eye Injuries/etiology , Facial Injuries/etiology , Adult , Blast Injuries/diagnosis , Blast Injuries/surgery , Craniocerebral Trauma/diagnosis , Craniocerebral Trauma/surgery , Explosions , Eye Injuries/diagnosis , Eye Injuries/surgery , Facial Injuries/diagnosis , Facial Injuries/surgery , Humans , Intracranial Hemorrhage, Traumatic/diagnosis , Intracranial Hemorrhage, Traumatic/etiology , Intracranial Hemorrhage, Traumatic/surgery , Male
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