ABSTRACT
It is established that remaxol influences the main links of cells antioxidant system in case of experimental drug-induced liver damage. The injection of remaxol to animals with hepatotoxic damage increases the level of restored glutathione and maintains the concentration of SH groups of proteins in liver tissues on the level typical of intact animals. Remaxol helps to keep intact the energetic substrates of hepatocytes by saving the activity of glucose-6-phosphatedehydrogenase (which increases restored NADPH and glutathione enzymes), thus preventing the oxidative destruction of glutathione reductase and glutathione S-transferase. The antioxidant effect has been also confirmed by the study of catalase and glutathione peroxidase activity, the concentration of which under the action of remaxol increased above the normal level. Additional evidence is a remaxol-induced decrease in concentration of the final products of lipid peroxidation.
Subject(s)
Antioxidants/pharmacology , Cyclophosphamide/toxicity , Liver/drug effects , Succinates/pharmacology , Animals , Cell Respiration/drug effects , Glucosephosphate Dehydrogenase/metabolism , Glutathione Reductase/metabolism , Lipid Peroxidation/drug effects , Liver/metabolism , MiceABSTRACT
Hepatoprotective effect of metabolism correctors has been studied on the model of experimental viral and toxic damage of the liver. Reamberin-based substrate compositions (cytoflavin and remaxol) exhibit antihypoxic effect, antioxidant activity, and cytoprotective action on the background of metabolic effect. Based on these results, the indicated preparations are recommended for clinical trials on acute and chronic viral liver disorders.
Subject(s)
Antioxidants/pharmacology , Chemical and Drug Induced Liver Injury/drug therapy , Cytoprotection/drug effects , Hepatitis, Viral, Animal/drug therapy , Liver/metabolism , Meglumine/analogs & derivatives , Succinates/pharmacology , Animals , Chemical and Drug Induced Liver Injury/metabolism , Hepatitis, Viral, Animal/metabolism , Liver/injuries , Meglumine/pharmacology , MiceABSTRACT
Positive effects of angiogen, a preparation containing succinic and acetylsalicylic acids, on ECG, blood clotting, and lipid metabolism were demonstrated on animals with experimental cardiovascular disease induced by repeated injections of norepinephrine.
Subject(s)
Aspirin/pharmacology , Blood Pressure/drug effects , Cardiovascular Agents/pharmacology , Cardiovascular Diseases/drug therapy , Hemostasis/drug effects , Succinic Acid/pharmacology , Animals , Blood Coagulation/drug effects , Cardiovascular Diseases/blood , Cardiovascular Diseases/chemically induced , Cardiovascular Diseases/physiopathology , Cholesterol/blood , Drug Combinations , Lipids/blood , Male , Platelet Aggregation Inhibitors/pharmacology , RatsABSTRACT
Experiments on rodents showed that pentifin, a muscarine antagonist belonging to the group of acetylene amines, possesses a pronounced antiparkinsonian activity. Pentifin is superior in the breadth of therapeutic action and tolerance characteristics to the conventional agents used for Parkinson's disease treatment.
Subject(s)
Acetylene/analogs & derivatives , Acetylene/therapeutic use , Amines/therapeutic use , Antiparkinson Agents/therapeutic use , Muscarinic Antagonists/therapeutic use , Acetylene/adverse effects , Acetylene/pharmacology , Amines/adverse effects , Amines/pharmacology , Amines/toxicity , Animals , Antiparkinson Agents/adverse effects , Antiparkinson Agents/pharmacology , Antiparkinson Agents/toxicity , Catalepsy/chemically induced , Catalepsy/drug therapy , Convulsants , Disease Models, Animal , Dose-Response Relationship, Drug , Drug Antagonism , Drug Evaluation, Preclinical , Haloperidol , Heart Rate/drug effects , Lethal Dose 50 , Memory, Short-Term/drug effects , Mice , Muscarinic Antagonists/adverse effects , Muscarinic Antagonists/pharmacology , Muscarinic Antagonists/toxicity , Pentylenetetrazole , Rats , Seizures/chemically induced , Seizures/drug therapyABSTRACT
It has been demonstrated in rat experiments that intraperitoneal injection of 100 mg/kg phenazepam immobilizes the animals for one hour, causes long-term diminution of the muscular tonus and disturbed coordination of movements, tachycardia, hypotension, hyperthermia, depression of orientation and exploration motor activity, and disturbance of conditioned reflexes of active and passive avoidance. It is concluded that the changes in the above-indicated parameters of autonomic and behavioral status of rats under the effect of a 100 mg/kg dose of phenazepam are clearly expressed for a long period of time, are specific to the effect of benzodiazepines and may therefore serve as a model of severe BD intoxication for evaluating the efficacy of their antidotes. This has been confirmed in experiments with the well-known BD antagonist phlumazelin.
