ABSTRACT
Thirty biopsies of the lower lip mucosa from patients with clinical and subclinical manifestations of Sjögren syndrome were studied. The results indicate characteristic morphological changes in small salivary glands. The dynamics of these changes consists in progressive lymphoid infiltration of the gland tissue and includes 4 stages: I--weak lymphoid infiltration, II--focal lymphoid infiltration, III--focal-extensive lymphoid infiltration, IV--diffuse lymphoid infiltration, that is, lymphomatosis. In parallel with the progressive lymphoid infiltration there occur sclerosis of the stroma, atrophy and loss of parenchyma of the salivary glands in which the chemical composition of the secrete is changes as confirmed by tests done for mucus. The results obtained and data from literature permit a conclusion that Sjögren syndrome is a generalized autoimmune disease underlain by the disturbance of immunological homeostasis.
Subject(s)
Mouth Mucosa/pathology , Sjogren's Syndrome/diagnosis , Adult , Biopsy , Chronic Disease , Female , Hepatitis/diagnosis , Humans , Keratoconjunctivitis/diagnosis , Lip/pathology , Lupus Erythematosus, Systemic/diagnosis , Middle Aged , Salivary Glands/pathology , Scleroderma, Systemic/diagnosis , Sjogren's Syndrome/pathology , Xerostomia/diagnosisABSTRACT
The article sets forth clinico-anatomical characteristics of Burkkit's lymphoma (50 observations). The investigation was carried out in the granted hospital in Kenya, were the authors had worked from 1967 to 1971. A histological feature of the tumour was a peculiar picture of the "starry sky", which was associated with the presence of large histiocytesmacrophages among prolypherating lymphoid cells, a cytological feature being the availability of vacuoles in the nucleus and cytoplasma. In the majority of cases Burkkit's tumour had multicentrical growth, most often localizations were jaws and ovaries. The authors observed in some cases considerable therapeutic effect of chemical preparations.
