[Peculiarities of amino acids transformation in brain under conditions of acute hypoxic hypoxia]. / Osobennosti prevrashchenii aminokislot v mozge v usloviiakh ostroi gipoksicheskoi gipoksii.

Acute 15, 30 and 60-minute hypoxia induced in a rabbit placed in the altitude chamber at the atmospheric pressure of 260 mm Hg was an experimental model for a hypoxic state. An increase in the amount of aspartate in the brain under conditions of 15-minute hypoxia and its decrease with prolongation of the hypoxia period up to 1 h may be explained by different mechanisms of amino acids metabolic transformations under these conditions. Changes in the content of aspartate are adequate to these in the activity of aspartate aminotransferase. An increase in the glutamate content in the brain the 30- and 60-minute hypoxic effect is accompanied by a rise of the activity in the glutamine synthesis enzyme (glutamine synthetase). Dynamics of the aspartate quantitative changes in the brain in different periods of acute oxygen deficiency affecting metabolic shifts in amino acids metabolism may serve as an index of the hypoxic effect gravity.