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[DNA-dependent RNA-polymerase of the organs of irradiated animals. Report 6. Role of enzyme changes in disturbance of the process of transcription]. / DNK-zavisimaia RNK-polimeraza organov obluchennykh zhivotnykh. Soobshchenie 6. Rol' izmenenii fermenta v narushenii protsessov transkriptsii

Likhoded, V S; Stoliarov, I V; Savenko, L N; Paskevich, I F.

Radiobiologiia ; 15(5): 741-4, 1975.

Article in Russian | MEDLINE | ID: mdl-1108099

Subject(s)

DNA-Directed RNA Polymerases/radiation effects , Liver/enzymology , Radiation Genetics , Spleen/enzymology , Transcription, Genetic/radiation effects , Animals , DNA/radiation effects , DNA-Directed RNA Polymerases/biosynthesis , Liver/radiation effects , Rats , Spleen/radiation effects

[DNA-dependent RNA polymerase in the organs of irradiated animals. 5. Physicochemical changes in the enzyme molecules]. / DNK-zavisimaia RNK-polimeraza organov obluchennykh zhivotnykh. Soobshchenie 5. Fiziko-khimicheskie izmeneniia molekul fermenta

Likhoded, V S; Savenko, L N; Paskevich, I F.

Radiobiologiia ; 15(3): 423-7, 1975.

Article in Russian | MEDLINE | ID: mdl-1188027

Subject(s)

DNA-Directed RNA Polymerases/metabolism , Liver/enzymology , Radiation Injuries, Experimental/enzymology , Spleen/enzymology , Animals , Male , Rats

[DNA-dependent RNA polymerase from the nuclei of the spleen of white rats]. / DNK-zavisimaia RNK-polimeraza iz iader selezenki belykh krys

Paskevich, I F; Likhoded, V S; Ishkhanova, M A; Savenko, L N.

Biokhimiia ; 40(1): 8-12, 1975.

Article in Russian | MEDLINE | ID: mdl-1139003

ABSTRACT

DNA-dependent RNA polymerase was isolated from rat spleen cell nuclei and was identified as A and B RNA polymerases by data on DEAE- and P-cellulose ionic exchange chromatography and on concentration dependency on bivalent ions and (NH4)2SO4. Two forms of the enzyme differed from each other in the activity in RNA synthesizing system, and their activity was completely inhibited by actinomycin, DNase and RNase.

Subject(s)

Cell Nucleus/enzymology , DNA-Directed RNA Polymerases/isolation & purification , DNA/pharmacology , Spleen/cytology , Ammonium Sulfate/pharmacology , Animals , Cell Fractionation , Chlorides/pharmacology , Chromatography, DEAE-Cellulose , Dactinomycin/pharmacology , Deoxyribonucleases/pharmacology , Electrophoresis, Polyacrylamide Gel , Enzyme Activation/drug effects , Magnesium/pharmacology , Male , Manganese/pharmacology , Rats , Ribonucleases/pharmacology , Rifampin/pharmacology , Spectrophotometry

[DNA-dependent RNA polymerase from albino rat liver and spleen nuclei]. / DNK-zavisimaia RNK-polimeraza iz iader pecheni i selezenki belykh krys

Paskevich, I F; Savenko, L N; Likhoded, V S.

Dokl Akad Nauk SSSR ; 217(2): 476-8, 1974 Jul 11.

Article in Russian | MEDLINE | ID: mdl-4848536

Subject(s)

DNA-Directed RNA Polymerases/metabolism , Liver/enzymology , Spleen/enzymology , Animals , Carbon Radioisotopes , Cell Nucleus/enzymology , Chromatography, DEAE-Cellulose , DNA-Directed RNA Polymerases/isolation & purification , Rats , Tritium

[DNA-dependent RNA polymerase of irradiated animal organs. 2. Nucleoplasmatic RNA-polymerase (form B) of liver and spleen nuclei of white rats]. / DNK-zavisimaia RNK-polimeraza organov obluchennykh zhivotnykh. Soobshchenie 2. Nukleoplazmaticheskaia RNK-polimeraza (forma B) iz iader pecheni i selezenki belykh krys

Likhoded, V S; Savenko, L N; Paskevich, I F.

Radiobiologiia ; 14(4): 576-9, 1974.

Article in Russian | MEDLINE | ID: mdl-4438612

Subject(s)

Cell Nucleus/radiation effects , DNA-Directed RNA Polymerases/radiation effects , DNA/radiation effects , Liver/radiation effects , Radiation Effects , Spleen/radiation effects , Animals , Cell Nucleus/enzymology , Chromatography , DNA-Directed RNA Polymerases/analysis , Liver/cytology , Liver/enzymology , Male , Radiation Dosage , Rats , Spleen/cytology , Spleen/enzymology

[Isoforms of nuclear DNA-dependent RNA polymerases in the rat liver and spleen]. / Izoformy DNK-zalezhnoï RNK-polimerazy iader pechinky i selezinky shchuriv

Lykhodid, V S; Savenko, L N; Ishkhanova, M A; Paskevich, I F.

Ukr Biokhim Zh ; 46(3): 328-32, 1974.

Article in Ukrainian | MEDLINE | ID: mdl-4836937

Subject(s)

Cell Nucleus/enzymology , DNA-Directed RNA Polymerases/metabolism , DNA/metabolism , Liver/enzymology , Spleen/enzymology , Ammonium Sulfate/metabolism , Animals , Carbon Radioisotopes , Cations, Divalent , Chromatography, DEAE-Cellulose , DNA-Directed RNA Polymerases/isolation & purification , Electrophoresis, Polyacrylamide Gel , Liver/cytology , Magnesium/metabolism , Manganese/metabolism , Rats , Spectrophotometry , Spleen/cytology

[Effect of radiation on matrix activity of deoxyribonucleoproteins from rat liver and spleen]. / Vliianie oblucheniia na matrichnuiu aktivnost' dezoksiribonukleoproteidov iz pecheni i selezenki krys.

Paskevich, I F; Likhoded, V S; Fonarev, A B; Savenko, L N; Ishkhanova, M A.

Radiobiologiia ; 13(6): 902-6, 1973.

Article in Russian | MEDLINE | ID: mdl-4592312

Subject(s)

Liver/radiation effects , Nucleoproteins/metabolism , RNA/biosynthesis , Radiation Effects , Spleen/radiation effects , Animals , DNA/metabolism , DNA-Directed RNA Polymerases/metabolism , Escherichia coli/enzymology , Male , Rats

[Properties of chromosomal deoxyribonucleoprotein complexes from the organs of irradiated animals]. / Svoistva khromosomnykh dezoksiribunukleoproteidnykh kompleksov iz organov obluchennykh zhivotnykh.

Likhoded, V S; Stoliarov, I V; Ishkhanova, M A; Savenko, L N; Fonarev, A B.

Radiobiologiia ; 12(6): 819-25, 1972.

Article in Russian | MEDLINE | ID: mdl-4665046

Subject(s)

Chromosomes/radiation effects , DNA/radiation effects , Liver/radiation effects , Proteins/radiation effects , Radiation Effects , Spleen/radiation effects , Animals , Carbon Isotopes , Histones/radiation effects , Male , Rats , Time Factors

[Ribonuclease activity in the organs of irradiated animals]. / Issledovanie ribonukleaznoi aktivnosti v organakh obluchennykh zhivotnykh.

Paskevich, I F; Shantyr', V I; Savenko, L N; Ishkhanova, M A; Likhoded, V S.

Radiobiologiia ; 12(2): 180-5, 1972.

Article in Russian | MEDLINE | ID: mdl-5080524

Subject(s)

Cell Nucleus/enzymology , Cytoplasm/enzymology , Liver/enzymology , Radiation Effects , Ribonucleases/metabolism , Spleen/enzymology , Animals , Male , Rats

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