1.
Med Radiol (Mosk)
; 25(3): 9-12, 1980 Mar.
Article
in Russian
| MEDLINE
| ID: mdl-7374391
2.
Farmakol Toksikol
; 39(5): 598-600, 1976.
Article
in Russian
| MEDLINE
| ID: mdl-1028587
ABSTRACT
Pharmacokinetics of phosphamide-32P was studied in experiments on rats with sarcoma 45 and intact (tumourless) ones. Soon (15 min to 1 hour) after intraperitoneal injection of the compound the maximum amount of the isotope was definable in the liver, kidneys, spleen, suprarenals, in the tumour and the thymus. The content of the compound in the tumour ammounted to 0.2--0.4 per cent of the radioactivity introduced. Distribution of phosphemide-32P among organs and tissues of the rats with sarcoma 45 quatitatively differs from that in intact animals. During the first 24 hours 55--56 per cent of the radioactivity introduced is excreted together with urine.