[Effect of probucol on cardiac electrophysiology in anginal patients with hyperlipidemia and diabetes mellitus type II]. / Vliianie probukola na élektrofiziologicheskie parametry serdtsa u bol'nykh stenokardiei, sochetaiushcheisia s giperlipidemiei i sakharnym diabetom tipa 2.

AIM: To investigate effects of a hypolipidemic drug with antioxidant action probucol on electrophysiological parameters of the heart in patients with ischemic heart disease (IHD), stable angina (SA), hyperlipoproteinemia (HLP) and diabetes mellitus (DM) type II. MATERIAL AND METHODS: The trial entered 48 IHD patients (11 males and 37 females) aged 47-73 years with SA functional class II and III (39.4 and 60.6%, respectively), secondary HLP (mean group total cholesterol 6.5 +/- 0.17 mmol/l), DM type II (mean fast glucose 7.7 +/- 1.8 mmol/l) and obesity (mean body mass index 29.7 +/- 2.2 kg/m2). Transesophageal pacing of the left ventricle was conducted in all the patients before probucol treatment and 18 hours, 1 month and 3 months after it. RESULTS: Probucol (a single dose 500 mg) significantly reduced the time of recovery of sinus node function. Three months of probucol administration in a dose 1000 mg/day enhanced pacemaker activity of the sinus node. CONCLUSION: In addition to a beneficial effect on lipid metabolism (a decrease of total cholesterol by 13.4%, LDLP cholesterol by 15.2%, triglycerides by 15.8%), probucol enhanced pacemaker activity of the sinus node. This makes it perspective in patients with sinus node dysfunction. Caution is necessary in prescribing probucol to patients with supraventricular tachycardia caused by re-entry mechanism.

[Features of angina pectoris in patients with non-insulin-dependent diabetes mellitus (NIDDM)]. / Osobennosti stenokardii u bol'nykh s insulinnezavisimym sakharnym diabetom.

Detailed clinicofunctional examination of anginal patients with NIDDM using variation pulsometry and electrophysiological cardiac tests in 110 patients (89 females and 21 males aged 36-79 years, mean 64.3 +/- 5.2 years) has revealed that atypical cardialgia, arterial hypertension, obesity was present in 28.1, 76.4 and 85.4% of anginal patients with NIDDM. Sympathicotonia was registered in autonomic heart regulation of 83% of them. Anginal patients exhibited also suppression of sinus node automatism and sinoatrial conduction. When NIDDM is severe, pacemaker activity of the sinus node intensified suggesting development of cardial diabetic neuropathy.

[The use of graded walking with hypertension patients]. / Primenenie dozirovannoi khod'by u bol'nykh gipertonicheskoi bolezn'iu.

Different walking regimens adjusted in duration and intensity to the circulation functional class were prescribed to patients with essential hypertension (EH) stage I and II. Functional class of the circulation was determined at bicycle exercise, the motor regimen was under the control of ECG Holter monitoring. Regular walking improved the patients' health, lowered blood pressure, enhanced physical performance. The authors advocate graded walking as one of nonpharmacological forms of outpatient EH therapy.