ABSTRACT
Arterial hypertension (AH) is one of the most widespread cardiovascular disorders, 39.2% of men and 41.1% of women having elevated arterial pressure (AP). Hence, the necessity to elucidate possible causes of this abnormality. Heredity is considered to be a major factor determining AP in humans, and researchers all over the world are engaged in the search for AP markers. This paper is focused on genes controlling the renin-angiotensin-aldosterone system, viz. genes of angiotensin II, type 1 angiotensin II receptors, angiotensin-converting enzyme, and NO synthase. An overview of population studies with special reference to these genes indicates that molecular-genetic mechanisms of AH remain unclear. Joint efforts of researchers working in different centres are needed to address the problem.
Subject(s)
Gene Expression/genetics , Hypertension/genetics , Nitric Oxide Synthase/genetics , Renin-Angiotensin System/genetics , HumansABSTRACT
Dilated cardiomyopathy (DCMP) is a non-coronary heart disease, which leads to the severe degenerative changes and destruction of cardiomyocytes, heart chamber dilatation, systolic and diastolic myocardial dysfunction, steady heart failure progression, disability, and high mortality. HIV is considered to be one of the possible causes of DCMP. Heart involvement in AIDS influences prognosis by lowering survival rate. The number of HIV-infected patients grows in our country; thus, the number of patients with various AIDS manifestations is going to grow, too. In this article the authors adduce the observation of DCMP development in a HIV-infected patient.
