[Testosterone, albumin and sex steroid-binding globulin in the blood serum of patients with laryngeal cancer]. / Testosteron, al'bumin i globulin, sviazyvaiushchii polovye steroidy, v syvorotke krovi bol'nykh rakom gortani.

Since endocrine factors play a role in the etiology and pathogenesis of precancerous and tumor diseases of the pharynx, the study was concerned with assays of total testosterone, albumin, sex steroid-binding globulin and free and protein-bound androgens in the blood serum of patients with malignant and benign tumors of the larynx. Laryngeal cancer patients revealed raised levels of total, free and albumin-bound testosterone matched by a lower concentration of sex steroid-binding globulin. Maximum differences between the study groups were established in the relationship between the fraction of testosterone associated with sex steroid-binding globulin and that of free androgen. An important role of androgens in the pathogenesis of laryngeal cancer was inferred. Further studies of androgen secretion and transport by blood proteins in laryngeal cancer patients are essential for the investigations of pathways of sex steroid hormones action.

[Radioimmunoassay in the evaluation of the hormonal state of patients with malignant tumors of the female genitalia]. / Radioimmunologicheskii analiz v otsenke sostoianiia gormonal'nogo profilia u bol'nykh so zlokachestvennymi opukholiami zhenskoi polovoi sfery.

Using a radioimmunoassay of hormones, disorders in the system of hormonal relations were revealed in 210 patients with malignant ovarian and corpus uteri tumors and correlated with a clinical course of disease. The recovery of the hormonal balance can serve an objective criterion for the evaluation of therapeutic efficacy and for a search for new antitumor drugs and means of correction of the disturbed feedback between hypophyseal and ovarian functions as one of the main factors of the pathogenesis of malignant ovarian and corpus uteri tumors. The author describes the importance of radionuclide methods in vitro for an all-round control over changes in the respective components of the neuroendocrine system in treatment of dyshormonal tumors and possibilities of their use in screenings of the hormonal status.

[Changes in antitumor resistance during chemical carcinogenesis]. / Izmenenie protivoopukholevoi rezistentnosti v protsesse khimicheskogo kantserogeneza.

Subcutaneous injection of 4 mg DMBA to noninbred rats leads to a considerable decrease in host resistance to cancer, which progresses with tumor growth. The rats with inhibited host resistance to cancer accepted well, at the stage of tumor germ, the DMBA-induced tumors from other animals, permitting them to grow--the phenomenon that was not observed in normal noninbred young rats. At the stage of clinically demonstrable nodules at the sites of DMBA injections, the tumors with different transplantability did not only get adapted but developed distant metastases in part of the animals.

[Functional reserves of the pituitary gland in patients with trophoblastic uterine tumors]. / Funktsional'nye rezervy gipofiza u bol'nykh s trofoblasticheskimi opukholiami matki.

In patients with chorionepithelioma as distinct from the normal postnatal period hypothalamohypophyseal function has been shown to get loose without the parallel elimination of the hormones of the fetoplacental complex from the body, particularly of chorionic gonadotrophin.

[Effect of malignant tumors with various characteristics on the state of the estradiol receptor system in peripheral target organs]. / Vliianie zlokachestvennykh opukholei raznoi kharakteristiki na sostoianie éstradiol-retseptornoi sistemy v perifericheskikh organakh-misheniakh.

Experiments on 24 randombred rats with growing lymphosarcoma and mammary carcinoma have demonstrated alterations in steroid-producing function of the ovaries and adrenals and in the estradiol-receptor system. These alterations were found to be inconclusive and dependent on the characteristics of the growing tumor. In rats bearing lymphosarcoma, the reduced estradiol levels in the blood and ovaries were in agreement with a negligible number of cytoplasmic and nuclear receptors in the uterus, mammary glands and tumor. Rats with mammary carcinoma demonstrated an increase in estradiol levels in the blood, ovaries and adrenals and a dramatic fall in the blood progesterone level. In this case the number of cytoplasmic receptors in the uterus and mammary glands decreased, whereas that in the nucleus dramatically rose. The measurement of the number of estradiol molecules in the nucleus and cytoplasm and its correlation to the receptor number made it possible to reveal substantial differences between the estradiol-receptor systems in the two tumors regardless of the low level of receptors in both tumors.

[Pituitary gonadotropic function in uterine trophoblastic tumor]. / Gonadotropnaia funktsiia gipofiza u bol'nykh s trofoblasticheskimi opukholiami matki.

A simultaneous determination of 3 gonadotropic hormones of the hypophysis (follitropin, lutronin and prolactin) using a radioimmunoassay in 33 patients with trophoblastic uterine tumors and 22 women on the 1st-8th day after normal delivery, has shown that there are not only significant differences in the nature of the secretion of hypophyseal gonadotropic hormones in pathology as compared to the normal postnatal period but also differences in different forms of trophoblastic tumors. These differences were characterized by a progressive, according to the severity of disease, independence between trophoblastic tissue function and gonadotropic function of the hypophysis. A marked suppression of follicle-stimulating function of the hypophysis after normal delivery decreased hydatidiform mole and trophoblastic tumors and was not observed in patients with chorioepithelioma of the uterus.

[Radioimmunologic determination of several hormones in commercial immunoglobulin preparations]. / Radioimmunologicheskoe opredelenie nekotorykh gormonov v kommercheskikh preparatakh immunoglobulinov.

Radioimmunological method with the aid of standard sets was applied to determination of the content of chorionic gonadotropin, placental lactorgen, prolactin, folliculo-stimulating and luteinizing hormones in the immunoglobulin preparations made of abortion and placental blood serum. Serum fractionation by Cohn's method (technological variant B) led to reduction in the immunoglobulin preparations of polypeptide hormones (placental lactogen and prolactin) content, but it was not sufficiently effective in respect to glucoprotein hormones.

[Use of an immunologic test for differential diagnosis of uterine chorionepithelioma and hydatid mole]. / Ispol'zovanie immunologicheskoi reaktsii dlia differentsial'noi diagnostiki khorionépiteliomy matki i puzyrnogo zanosa

Polysaccharide complexes obtained by Westphal's method (modified by L. A. Zilbert et al) from the tissue of a primary tumour node and remote metastases (the lungs) of chorionoepithelioma of the uterus were used for differential diagnosis of chorionepithelioma of the uterus and hydatid mole. Investigations carried out showed that the reaction to the intradermal injection of polysaccharide complexes obtained from the remote metastases (the lungs) of chorionepithelioma of the uterus was highly specific and sensitive: positive reaction occurred only in the patients with chorionepithelioma of the uterus, and it was negative in the patients with hydatid mole. With a marked diminution (in the course of chemotherapy) of metastases in the lungs, when the immunological reaction to chorionic gonadotropin fell to 300--100 IU per litre of the urine, reaction to the intradermal injection of polysaccharide complexes from the metastases of chorionepithelioma of the uterus still remained positive.