ABSTRACT
There have been obtained high-filling polyurethane compositions with hydroxyapatite. Compositions with hydroxyapatite and immunomodulator in the polyurethane base acquire better adhesiveness and improved strength characteristics as evidenced by physical-and-clinical studies made. Modal operations are developed in test animals on bone defects replacing that carry a high mechanical load. Histological studies showed that polyuretane-base high-filling polymeric compositions replace the loss of bone fully, stimulate the processes of bone formation, with no negative responses of the osseous tissue noted.
Subject(s)
Bone Cements , Durapatite , Implants, Experimental , Polyurethanes , Animals , Biocompatible Materials , Bone Diseases/therapy , RabbitsABSTRACT
Results of experimental investigations of using polymer compositions KL-3, including modifications with ionol ("Adgenol") and levamisol in 18 rabbits with injuries of the liver are presented. It has been established that 3 and 6 months after using the mentioned compositions viable healing of liver wounds are obtained. Different degrees of intensity of inflammatory reactions and of development of the connective tissue were noted, most pronounced after using "Adgenol". Adding Levamizol to the polymer composition facilitated the recovery of the initial hepatic cells.
Subject(s)
Hemostatics/pharmacology , Liver Regeneration/drug effects , Polyurethanes/pharmacology , Tissue Adhesives/pharmacology , Animals , Butylated Hydroxytoluene/pharmacology , Levamisole/pharmacology , Liver/drug effects , Liver/pathology , Liver/surgery , Rabbits , Time FactorsABSTRACT
By the method of tissue culture, it is established that the capron threads stained by brilliant green, coated with the chemosorbed substances on the base of titanium alkoxides, polyalkylhydridsiloxanes and polyorganilsiloxanes have no histotoxic properties and can be used in microsurgical practice.
