ABSTRACT
The efficacy and safety of fluconazole, a new triazole antifungal agent, was evaluated in 24 patients with neutropenia due to cytotoxic anticancer chemotherapy with polyfactorial immunodepression. Twenty of 23 patients benefited from treatment, and except for 1 patient with mild abdominal discomfort the drug was well tolerated. Mycological eradication appeared in 17 from 23 evaluable patients, superinfection in 1 case and persistence could be evaluated in 5 cases. Candida albicans, C. crusei and C. pseudotropicalis together with Torulopsis sp. were the most frequently isolated organisms from pharyngeal and esophageal mucosa in treated patients with oropharyngeal and esophageal mycosis.
Subject(s)
Candidiasis, Oral/drug therapy , Esophagitis/drug therapy , Fluconazole/therapeutic use , Mycoses/drug therapy , Neutropenia/complications , Pharyngitis/drug therapy , Administration, Oral , Adult , Antineoplastic Agents/adverse effects , Drug Evaluation , Female , Fluconazole/administration & dosage , Humans , Injections, Intravenous , Male , Neoplasms/complications , Neutropenia/chemically inducedSubject(s)
Bacterial Infections/drug therapy , Cefoperazone/therapeutic use , Respiratory Tract Infections/drug therapy , Surgical Wound Infection/drug therapy , Adult , Age Factors , Cefoperazone/administration & dosage , Cefoperazone/pharmacokinetics , Child , Dose-Response Relationship, Drug , Drug Evaluation , HumansABSTRACT
Comparative analysis of results after extracapsular cataract extraction (46 eyes) and intracapsular cataract extraction (58 eyes) in 88 patients with recurrent uveitis has shown that after extracapsular extraction complications occur rarer than after intracapsular cataract extraction. Exudative reaction was observed equally frequently both in surgical intervention at the period of remission, and in the presence of moderate signs of uveitis. Both methods allowed to achieve high visual acuity in 58% of cases; the cause of low visual acuity was atrophy of the optic nerve, chorioretinitis, opacification of the vitreous body, secondary cataract. In remote terms of observation, no recurrences of the disease were recorded in 82% of cases, this speaking about the fact that removal of opaque lens prevents possible autosensitizing influence of a lenticular antigen on the eye coats.
Subject(s)
Cataract Extraction , Cataract/complications , Uveitis/surgery , Cataract Extraction/methods , Chronic Disease , Female , Follow-Up Studies , Humans , Male , Postoperative Complications/epidemiology , Recurrence , Uveitis/complications , Visual AcuityABSTRACT
The purpose of a new method elaborated for treatment of allergic inflammation of the eye is to rise effectiveness of treatment and to prevent exacerbation of allergic inflammation by means of increasing the accuracy of determining the therapeutic allergen dilution when conducting specific hyposensitization. This is achieved in the following way: in addition to control, when conducting allergometric titration, the syringe needle is introduced intracutaneously without subsequent administration of the allergen. In respective terms, the thermometry of skin is made in the sites of administration of different allergen dilutions and in the control site. Considering the minimum hyperthermia in the site of administration of the highest allergen dilution as compared with the control site, the therapeutic allergen dilution is chosen. This method of treatment was used in 38 patients (54 eyes) with recurrent uveitis and proved to be highly effective in 34 patients (50 eyes), i.e. in 92%. In remote terms of observation, no further recurrences were recorded in 65% of cases.
