ABSTRACT
The paper gives the results of a study of energy metabolism in the red blood cells of the workers from OAO "Salavatnefteorgsinthez" of petrochemical industry. The energy metabolism has been found to substantially change in the examinees in contact with a mixture of organic solvents and a mixture of chlorinated solvents under industrial conditions.
Subject(s)
Environmental Pollutants/toxicity , Erythrocytes/drug effects , Hydrocarbons, Chlorinated/toxicity , Occupational Exposure/adverse effects , Solvents/toxicity , Adenine Nucleotides/blood , Adenosine Triphosphatases/blood , Chemical Industry , Energy Metabolism , Erythrocytes/metabolism , Humans , Phosphotransferases (Alcohol Group Acceptor)/bloodABSTRACT
The paper gives the results of studying the processes of free radical and microsomal oxidation, antioxidant defense, and energy and electrolyte metabolism in the workers of OAO "Salavatnefteorgsintez", one of the leading petrochemical plants in the Republic of Bashkortostan. The metabolic processes have been found to substantially change in the persons contacting a mixture of chlorinated and aromatic hydrocarbons under industrial conditions.
Subject(s)
Environmental Pollutants/toxicity , Occupational Exposure/adverse effects , Air Pollutants, Occupational/toxicity , Antioxidants/analysis , Chemical Industry , Energy Metabolism , Free Radicals/analysis , Humans , Microsomes/metabolism , Oxidation-Reduction , Petroleum , Water-Electrolyte BalanceABSTRACT
The paper gives the results of studying the free radical oxidation-antioxidant defense (FRO-AOD) system in the blood, saliva, and urine of workers from the petrochemical industry OAO "Salavatnefteorgsintez". The FRO-AOD system has been ascertained to be considerably changed in the plasma, tear, and urine of persons contacting a mixture of petrol and Grade BP-1 solvent with organic solvents and aromatic hydrocarbons and a mixture of 1,2-dichloroethane with chlorinated hydrocarbons under industrial conditions.
Subject(s)
Air Pollutants, Occupational/toxicity , Antioxidants/metabolism , Enzymes/analysis , Free Radicals/analysis , Occupational Exposure/adverse effects , Enzymes/blood , Enzymes/urine , Female , Free Radicals/blood , Free Radicals/urine , Humans , Luminescent Measurements , Male , Occupational Diseases/chemically induced , Oxidation-Reduction , Risk Assessment , Saliva/chemistrySubject(s)
Antioxidants/therapeutic use , Carbon Tetrachloride Poisoning/drug therapy , Carbon Tetrachloride/antagonists & inhibitors , Lipid Peroxidation/drug effects , Liver Diseases/drug therapy , Uracil/analogs & derivatives , Animals , Antioxidants/pharmacology , Carbon Tetrachloride/toxicity , Carbon Tetrachloride Poisoning/metabolism , Catalase/analysis , Catalase/metabolism , Chemical and Drug Induced Liver Injury , Glucosephosphate Dehydrogenase/analysis , Glucosephosphate Dehydrogenase/metabolism , Liver/drug effects , Liver/metabolism , Male , Rats , Rats, Inbred Strains , Uracil/pharmacology , Uracil/therapeutic useABSTRACT
Bashkirsky State Medical University served as an example for evaluating role of higher education institution in development of medical staffers in the region and their health care.
Subject(s)
Education, Medical, Continuing/standards , Occupational Health , Schools, Medical , HumansABSTRACT
Actoprotecting properties ofbemitil, tietasol in combination with atropin were studied in red cell membranes and lipid peroxidation of rats poisoned with MI in a dose 320 mg/kg (0.9 LD50). Atropin treatment showed a low effect. The addition of bemitil and tietasol normalized electric charge and osmotic resistance in red cell membranes, activity of superoxide dismutase, catalase, glucose-6-phosphate dehydrogenase and content of lipid peroxidation products--ketodienes and TBA-reacting products. Efficacy of the combined treatment is due primarily to noncholinergic mechanism of action of bemitil and tietasol--stimulation of endogenic antioxidant systems of erythron and antiradical activity (bemitil).
