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1.
Bull Exp Biol Med ; 171(6): 704-706, 2021 Oct.
Article in English | MEDLINE | ID: mdl-34705169

ABSTRACT

Comparative analysis of blood sera from women with alcohol dependence and depressive disorders or from conditionally healthy women revealed reduced level of antibodies to dopamine, norepinephrine, serotonin, glutamate, and GABA in blood serum in women with dysthymic disorder and a depressive episode and their increased content in women with alcohol dependence in combination with depressive disorders.


Subject(s)
Alcoholism/immunology , Autoantibodies/blood , Depressive Disorder/immunology , Dysthymic Disorder/immunology , Alcoholism/blood , Alcoholism/complications , Alcoholism/physiopathology , Case-Control Studies , Depressive Disorder/blood , Depressive Disorder/complications , Depressive Disorder/physiopathology , Dopamine/blood , Dysthymic Disorder/blood , Dysthymic Disorder/complications , Dysthymic Disorder/physiopathology , Female , Glutamic Acid/blood , Humans , Middle Aged , Norepinephrine/blood , Serotonin/blood , gamma-Aminobutyric Acid/blood
2.
Ross Fiziol Zh Im I M Sechenova ; 102(10): 1246-52, 2016 Oct.
Article in Russian | MEDLINE | ID: mdl-30193442

ABSTRACT

The 74 persons, including the 39 persons with mental and behavioral disorders due to psychoactive substance use (PAS) and the 35 persons with subclinical forms of substance use, are examined. The olfactory EEG patterns, differing in narcological patients depending on the range of PAS used, are revealed. EEG markers of olfactory response to isopropanol, thymol and androstenone in combination with emotional evaluation, having hemispheric features, can be diagnostic and differential predictive factors for assessment of predisposition to mental and behavioral disorders due to PAS use.


Subject(s)
Behavioral Symptoms/physiopathology , Electroencephalography , Mental Disorders/physiopathology , Olfactory Cortex/physiopathology , Psychotropic Drugs/administration & dosage , Substance-Related Disorders/physiopathology , Adolescent , Adult , Female , Humans , Male
3.
Patol Fiziol Eksp Ter ; 60(3): 57-60, 2016.
Article in English | MEDLINE | ID: mdl-29244477

ABSTRACT

The purpose of study was evaluation of extra and intracellular cytokine production in blood cultures and cytokine-pain relationship at different stages od addiction. Methods: Classic and multiplex enzyme immunoassay, flow, cytometry, algometry, visual analogue scale were used in 34 abusers, 12 users and 20 control subjects. Results: Cytokine profile correlated with clinical parameters and pain sensitivity in abusers (mostly IL-6 and IL-1ß). IL-10 production is increased in episodic and systematic users. Activation of intracellular IL-6 synthesis was found in users. Both parameters are expected to affect the emotional evaluation of pain. Conclusion: To assess the predisposition to substance dependence most informative are balance of extra and intracellular production of IL-6 and IL-10 and algometry.


Subject(s)
Interleukin-10/blood , Interleukin-6/blood , Pain/blood , Substance-Related Disorders/blood , Adult , Disease Susceptibility/blood , Humans , Male
4.
Vestn Ross Akad Med Nauk ; (4): 468-74, 2015.
Article in Russian | MEDLINE | ID: mdl-26710531

ABSTRACT

OBJECTIVE: Our aim was to assess effect of antiasthenic drug adamantilbromphenylamine on the immune system and symptoms of asthenia in patients with non-psychotic mental disorders and to reveal possible criteria for prediction of treatment efficiency. METHODS: Uncontrolled study with interrupted time series was carried out. According to efficiency of treatment patients were divided into two groups (group 1 (n=21)--very much improved and much improved; group 2 (n=9)--minimally improved). Adamantilbromphenylamine was administered to patients as a monotherapy 100 mg a day for 28 days. Examination was conducted before and after therapy. Severity of asthenic symptoms according to MFI-20 scale was identified; cellular and humoral immunity parameters, mitogen-induced production of interleukins (IL) 1ß and IL 4 by immunocompetent cells of patients were assessed. RESULTS: 30 patients with non-psychotic mental disorders with predominance of asthenic symptomatology in clinical picture of the disease were examined. Before therapy every proband had over 60 points across 5 items of MFI-20 scale. As compared with control decrease of number of lymphocytes of CD3+-, HLA-DR+, CD16+-phenotypes; increase in the ratio of CD4+/CD8+; concentration of serum IgM; phagocytic activity of neutrophils were revealed. In the end of therapy in group 1, sum total of points of asthenia decreased up to 26(23-37) (p<0.001); in group 2--up to 57(47-61). Only in group 1 positive dynamic of immune parameters was revealed. It was shown that baseline level of proinflammatory cytokine IL 1ß in group with apparent therapeutic effect of the drug was reliably lower, than in group with minimal improvement (p=0.005). These differences remained also after course of therapy (p=0.042). CONCLUSION: Interrelationship of clinical-immunological effect of adamantilbromphenylamine has been revealed; intensity of production of IL 1ß may be considered as a criterion of prognosis of efficiency of treatment with adamantilbromphenylamine in patients with non-psychotic mental disorders.


Subject(s)
Antipsychotic Agents/administration & dosage , Asthenia/drug therapy , Immunity, Cellular , Mental Disorders/drug therapy , Adult , Asthenia/immunology , Asthenia/psychology , Dose-Response Relationship, Drug , Female , Humans , Male , Mental Disorders/immunology , Mental Disorders/psychology , Middle Aged , Prognosis , Young Adult
5.
Bull Exp Biol Med ; 159(6): 768-71, 2015 Oct.
Article in English | MEDLINE | ID: mdl-26519271

ABSTRACT

We performed immunophysiological examination of 144 men aged 17-25 years, patients with psychoactive substance dependence, episodic psychoactive drug users, and conditionally healthy individuals. Associations of proinflammatory cytokine production with age, sex, hormone levels, and olfactory and nociceptive indices were revealed in cases of psychoactive drug use and formation of addiction. Predictive models based on the use of androstenone aversion, pressure algometry testing, and immunological parameters were proposed.


Subject(s)
Cytokines/blood , Hormones/blood , Inflammation Mediators/blood , Nociception/physiology , Psychotropic Drugs , Smell/physiology , Substance-Related Disorders/blood , Substance-Related Disorders/psychology , Adolescent , Adult , Case-Control Studies , Humans , Male , Young Adult
6.
Article in Russian | MEDLINE | ID: mdl-26978055

ABSTRACT

OBJECTIVE: To reveal olfactory parameters of substance addiction formation through evaluation of predictive capability of olfactometry combined with laboratory-immunological methods. MATERIAL AND METHODS: Authors examined 156 people of both sexes aged 18-25 years. Three comparison groups with different attitudes towards psychoactive substances were formed as follows: people who do not use psychoactive substances (controls), episodic consumers (group at risk) and people with dependence syndrome. RESULTS: The occurrence of olfactory abnormalities in the anamnesis has immunological, psychological and behavioral correlates and is associated with earlier age of onset of substance consumption. The severity of aversive reactions to the test odorant is reduced already in the stage of episodic substance use and is associated with clinical signs of immune deficiency, suppression of cellular immunity and an increase in blood cortisol levels in substance abusers. CONCLUSION: Diagnostic and predictive modeling in the field of biological and clinical science of drug addiction is possible based on immunological and olfactory parameters.


Subject(s)
Immunologic Deficiency Syndromes/epidemiology , Olfaction Disorders/epidemiology , Smell , Substance-Related Disorders/epidemiology , 2-Propanol , Adolescent , Adult , Female , Ferritins/blood , Humans , Male , Olfaction Disorders/blood , Receptors, Transferrin/metabolism , Risk , Young Adult
7.
Patol Fiziol Eksp Ter ; (3): 38-43, 2015.
Article in Russian | MEDLINE | ID: mdl-26852594

ABSTRACT

Blood serum from 129 patients with opium addiction at different stages of the disease and 63 donors (control group) was examined for the presence of autoantibodies to the exciting and inhibitory amino acids glutamate and GABA. It was shown enhanced production of autoantibodies to glutamate and GABA. Dependence of the level and frequency of detec- tion of autoantibodies to glutamate and GABA on the stage of the disease was revealed.


Subject(s)
Autoantibodies , Glutamic Acid/immunology , Opioid-Related Disorders , gamma-Aminobutyric Acid/immunology , Adolescent , Adult , Autoantibodies/blood , Autoantibodies/immunology , Female , Humans , Male , Opioid-Related Disorders/blood , Opioid-Related Disorders/immunology
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