ABSTRACT
Bilateral lesions in the anterior or posterior cingulate cortex were performed in rats. After a recovery period, the rats were immobilized for 24 hours. Results showed that posterior lesions increased the severity of the stomach pathology under restraint and non-restraint conditions. Anterior lesions, on the other hand, attenuated the effects of immobilization on gastric pathology. The data were discussed in reference to telencephalic limbic mechanisms and stress.
Subject(s)
Gastric Mucosa/innervation , Gyrus Cinguli/physiology , Stomach Ulcer/pathology , Animals , Brain Mapping , Male , Neurons/physiology , Rats , Rats, Inbred Strains , Stress, Physiological/pathologyABSTRACT
Previous studies have shown that large hippocampal lesions increase the gastric pathology found in restrained and unrestrained animals. The present experiments investigated the effects of lesions in the two major afferent and efferent pathways of the hippocampus, i.e., the dorsal pathway through the fimbria-fornix and the ventral pathway in the entorhinal region, on gastric pathology in restrained and unrestrained rats. Result demonstrated that lesions in the ventral pathway produced an increased incidence of pathology whereas lesions in the fimbria-fornix did not. Neuroanatomical pathways which may mediate these effects are described