ABSTRACT
The paper presents data on comparison of the detection rate of renal dysfunction after cardiac surgery, by using the criteria developed by Cockroft-Gault, C. M. Mangano, L.-G. Andersson, and G. Zanardo. It is shown that it is expedient to calculate creatinine phosphokinase by the Cochroft-Gault formula that using a patient's individual parameters provides a more objective approach to making the diagnosis of renal dysfunction. The rate of development of renal dysfunctions in patients who have undergone cardiac surgery under extracorporeal circulation (EC) depends on the type of an operation and the duration and temperature of perfusion. By postoperative day 14, renal function became normal in the vast majority of patients. Renal function became chronic in 1% of the patients operated on the heart under EC.
Subject(s)
Cardiac Surgical Procedures , Extracorporeal Circulation , Kidney Diseases/diagnosis , Postoperative Complications/diagnosis , Diagnosis, Differential , Female , Humans , Kidney Diseases/etiology , Male , Postoperative PeriodABSTRACT
The paper gives the data of comparing the use of various formulas to calculate glomerular filtration rate (GFR) for the evaluation of postoperative renal function in cardiosurgical patients. GFR is shown to evaluate renal filterability with a high degree of reliability. Monitoring of GFR changes may characterize the progression of renal diseases. This indicator is an important predictor of the onset of renal insufficiency and the risk of complications due to chronic renal disease. Calculation of GFR in clinical practice enables the agents excreted owing to glomerular filtration to be dosed to prevent their potential toxicity.
Subject(s)
Glomerular Filtration Rate , Heart Diseases/physiopathology , Female , Heart Diseases/surgery , Humans , Kidney Failure, Chronic/diagnosis , Kidney Failure, Chronic/physiopathology , Male , Middle Aged , Postoperative Complications/diagnosis , Postoperative Complications/physiopathology , Postoperative PeriodABSTRACT
Subclinically insignificant glomerular filtration disturbances were found during operations under extracorporeal circulation. After termination of perfusion, dysfunction of the proximal portion of renal tubules was recorded in all patients. This may be associated with that the proximal tubules were more susceptible to ischemia. Further impairments of the distal portions of renal tubules suggest the persistence of ischemic lesions of the tubular apparatus.
