[Contemporary low-invasive, videoendoscopic and organ-sparing abdominal operations].

The paper presents the results of low-invasive, videosurgical, and organ-sparing operations, developed and performed by the authors. Original low-invasive techniques of external, external-and-internal and internal bile-duct drainage, and bile-duct endoprosthesis replacement have been performed in 25 patients with benign and malignant bile-duct strictures. Transcutaneous puncture drainage operations, including those combined with an original method of transdrainage sclerotherapy with nitric oxide, have been performed in 93 patients with postnecrotic pancreatic cysts. Endoscopic virsungotomy have been performed as part of the complex treatment of 43 patients with external pancreatic fistulas and 14 patients with polycystic head of pancreas. X-ray endovascular embolization has been performed in 7 patients with internal arterio-pancreatic fistulas. Program laparoscopic abdominal cavity sanation by an original method have been performed in 50 patients with diffuse peritonitis. The results of the study demonstrate high effectiveness of the methods, which in most cases can be applied as an alternative to conventional surgical interventions.

[Use of piperacillin-tazobactam in abdominal surgery]. / Primenenie piperatsillin/tazobaktama v abdominal'noi khirurgii.

Piperacillin/tazobactam (P/T) was used in the monotherapy of 40 patients with various inflammatory diseases of the abdominal cavity organs. P/T was administered as dropwise intravenous infusions in a single dose of 4/0.5 g 3 times a day for 5 to 17 days. In 82.5 per cent of the patients with infection of the abdominal cavity: severe postoperative purulent wounds, peritonitis of various etiology (biliary, serous-fibrinous, hemorrhagic fibrinous), postnecrotic cyst of the pancrease, abscesses of the liver and subhepatic space P/T proved to be highly efficient. The P/T monotherapy resulted in practically complete eradication of anaerobic microbes, coagulase negative staphylococci, enterobacteria and nonfermenting bacteria except for Pseudomonas aeruginosa in the inflammation foci.

[Effect of piperacillin/tazobactam on the anti-infection resistance in patients with infections in the peritoneal cavity]. / Vliianie piperatsillin/tazobaktama na sistemu antiinfektsionnoi rezistentnosti bol'nykh s infektsiei v briushnoi polosti.

The effect of the monotherapy with piperacillin/tazobactam (P/T) or tazocin on microflora of the mucous membranes of the nose and pharynx of 33 patients and the contents of the large intestine of 21 patients as well as on the immunological aspects (cellular and humoral factors) of the antiinfectious resistance systems (AIRS) in patients with abdominal cavity infection (ACI) was studied. Before the treatment serious impairment of the AIRS in all the patients was observed. The P/T monotherapy in a daily dose of 12/1.5 g at the average for 10 days had no unfavourable effect on the indices characterizing the phagocytic function of the neutrophils in the incompleted and completed variants, on the immunocompetent cells, hemolytic complement and the levels of IgM, IgG and IgA. No significant effect of the treatment on the mucosal microflora on the whole was detected. However, Neisseria spp. and Corynebacterium pseudodiphtheriticum were eradicated in the pharynx while the number of the Klebsiella pneumoniae [symbol: see text] Escherichia coli isolates from the pharynx mucosa increased. The number of the bifidobacteria in the contents of the large intestine significantly lowered while the number of the hemolyzing forms of enterococci and stapylococci increased. The investigation of the AIRS immunological aspects in the patient groups of different total (clinicomorphological) efficacy showed that the neutrophil phagocytic function was the efficacy predictor and P/T in its turn had an immunomodulating effect on the neutrophil phagocytic activity in the patients with ACI.

[Diagnosis of chronic hemorrhage in diseases of the small intestine]. / Diagnostika khronicheskikh krovotechenii pri zabolevaniiakh tonkoi kishki.

In a period of 10 years 38 patients received treatment in the clinic for iron deficiency anemia in whom the source of chronic blood loss was revealed in the small intestine. The radionuclide method for detecting concealed blood loss was most informative for the diagnosis (98%) of chronic intestinal hemorrhages, and was particularly important in cases with iron deficiency anemia of unclear genesis. Oral enterography was the most available method and sufficiently informative (32%) in the diagnosis of chronic hemorrhages from the small intestine. In 3-4 day, blood loss of more than 10 ml/24 h from the gastrointestinal tract verified by the radionuclide method but with the source of the bleeding not identified by instrumental methods, the indications for diagnostic laparotomy must be widened for careful examination of the small intestine.

[A method of sequential (intravenous and oral) use of ofloxacin in the treatment of patients with infections of organs of the peritoneal cavity]. / Metod posledovatel'nogo (vnutrivenno i vnutr') primeneniia ofloksatsina pri lechenii bol'nykh s infektsiiami organov briushnoi polosti.

Clinico-laboratory estimation of the efficacy and tolerance of ofloxacin used in succession, at first intravenously and then orally, in the treatment of 15 patients with infection of the abdominal cavity was performed. It was shown that after the use for a period of 10 years ofloxacin preserved its high antimicrobial activity against gram-positive and gram-negative organisms with multiple drug resistance and remained superior to the majority of broad spectrum antimicrobial agents by the number of susceptible isolates. The successive use of ofloxacin proved to be highly efficient. The total efficacy of the drug amounted to 80 percent and no side effects were recorded. The analysis of the microbiological state of the antiinfectious resistance system (AIRS) showed that the dysbiotic lesions on the mucosa of the upper respiratory tracts and large intestine detected in all the patients before the treatment with ofloxacin remained after the treatment. However, a change in the microflora responsible for dysbacteriosis was observed. The investigation of the immunological status of the AIRS suggested that the good and satisfactory results of the therapy with ofloxacin could to a significant extent be due to the proportion of the active neutrophils.