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Leuk Res ; 29(5): 517-26, 2005 May.
Article in English | MEDLINE | ID: mdl-15755504

ABSTRACT

Studies were done to investigate MLL gene aberrations using Conventional Cytogenetics, Southern blotting as well as FISH using a panel of probes on 218 cases which included 206 cases of pediatric/young adult ALL and 12 cases of infantile acute leukemias from Tata Memorial Hospital, India. The incidence of MLL gene rearrangements in acute lymphoblastic leukemia (ALL) was 9.4% which included infants as well as pediatric/young adults. In infantile group which included ALL as well as AML cases, MLL gene rearrangement was very common (75% frequency). Application of metaphase-FISH helped unravel MLL rearrangements not only as a result of translocations but also inversions, insertions, partial deletion, duplications, partial duplication-->self-fusion. Besides age, MLL gene rearrangements showed significant association with hyperleukocytosis, peripheral blood blast percentage and early Pre-B phenotype. Clinical outcome of patients with MLL gene rearrangements revealed unfavorable prognosis.


Subject(s)
Chromosome Aberrations , DNA-Binding Proteins/genetics , Gene Rearrangement , Leukemia, Myeloid, Acute/genetics , Precursor Cell Lymphoblastic Leukemia-Lymphoma/genetics , Proto-Oncogenes/genetics , Transcription Factors/genetics , Adolescent , Adult , Child , Child, Preschool , Female , Histone-Lysine N-Methyltransferase , Humans , In Situ Hybridization, Fluorescence , India , Infant , Karyotyping , Male , Mutation , Myeloid-Lymphoid Leukemia Protein , Prognosis
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