ABSTRACT
Isolation and characterization of the major chemical constituents from the stem bark of Radermachera xylocarpa. Chloroform extract of the powdered stem bark contains mainly two components: one is lapachol (91.2%) and second is alpha-lapachone (5.0%), which are reported herewith first time from this plant, in good quantity and purity.
Subject(s)
Naphthoquinones/isolation & purification , Plants, Medicinal/chemistry , Naphthoquinones/chemistrySubject(s)
Actinomycetales/metabolism , Antifungal Agents/isolation & purification , Antifungal Agents/chemistry , Chemical Phenomena , Chemistry, Physical , Chromatography, High Pressure Liquid , Fermentation , Magnetic Resonance Spectroscopy , Molecular Structure , Pyrans/chemistry , Pyrans/isolation & purificationABSTRACT
A new echinocandin type antifungal antibiotic, deoxymulundocandin, C48H77N7O15, was isolated from the culture filtrate and mycelia of a fungal culture, Aspergillus sydowii (Bainier and Sartory) Thom and Church var. nov. mulundensis Roy (Culture No. Y-30462). The structure was established by comparative GC-MS analyses of the derivatized acid hydrolysates of deoxymulundocandin and mulundocandin as well as by the high field NMR experiments (COSY, NOESY and DEPT).