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1.
Int J Dermatol ; 54(5): 499-508, 2015.
Article in English | MEDLINE | ID: mdl-25772615

ABSTRACT

Superficial acral fibromyxoma (SAF), also known as digital fibromyxoma, is a rare soft tissue tumor with a predilection for acral surfaces. Superficial acral fibromyxoma classically presents as a pink to flesh-colored nodule located on the subungual or periungual region of the hands or feet. It is typically slow-growing and asymptomatic, which, coupled with its nonspecific clinical appearance, presents a diagnostic dilemma to the dermatologist. As these features overlap with those of a multitude of differential diagnoses, it is imperative to have a good understanding of the characteristics on which the diagnosis of SAF is based. Superficial acral fibromyxoma was initially described in 2001, since when several case reports and literature reviews have contributed to our current understanding of these tumors. In this article, we will review the history, clinical features, diagnosis, and management of SAF. It is our hope that this systematic approach will help to facilitate the recognition and management of this distinct dermatologic entity.


Subject(s)
Fibroma , Fingers , Soft Tissue Neoplasms , Toes , Diagnosis, Differential , Fibroma/pathology , Fibroma/therapy , Humans , Soft Tissue Neoplasms/pathology , Soft Tissue Neoplasms/therapy
2.
Int J Dermatol ; 53(9): 1053-61, 2014 Sep.
Article in English | MEDLINE | ID: mdl-24697501

ABSTRACT

Poroma is a benign adnexal neoplasm of the terminal sweat gland duct. Although poromas have traditionally been thought to originate from the eccrine sweat gland, there have been cases of apocrine etiology as well. Eccrine and apocrine poromas typically present as erythematous or flesh-colored nodules on the palms and soles. As these features overlap with a multitude of differential diagnoses, it is imperative to have a firm understanding of the characteristics that make the diagnosis of poroma. In addition, the malignant counterpart to the poroma, the eccrine porocarcinoma, manifests in a similar nonspecific fashion. Case studies and literature reviews have contributed immensely to our present knowledge of poroma and porocarcinoma. Given the rarity of these neoplasms, however, there remains a relative paucity of information on atypical presentations and rates of malignant transformation. In this article, the epidemiology, clinical presentation, diagnosis, and management of poroma and porocarcinoma will be reviewed. This systematic approach may serve as a guide in navigating the diagnostic dilemma of these rare cutaneous lesions.


Subject(s)
Poroma/pathology , Sweat Gland Neoplasms/pathology , Biomarkers, Tumor/metabolism , Cyclin-Dependent Kinase Inhibitor p16 , Dermoscopy , Diagnosis, Differential , Humans , Neoplasm Proteins/metabolism , Poroma/metabolism , Poroma/therapy , Risk Factors , Sweat Gland Neoplasms/metabolism , Sweat Gland Neoplasms/therapy , Tumor Suppressor Protein p53/metabolism
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