1.
Bioorg Med Chem Lett
; 14(12): 3177-80, 2004 Jun 21.
Article
in English
| MEDLINE
| ID: mdl-15149670
ABSTRACT
The synthesis and pharmacological evaluation of substituted oximino-ethers 1 and 2 of naphth[1,2-b]- and naphth[2,1-b]-oxepin-5-ones (4 and 8) were carried out. The hypotensive activity of oximino-ethers 1 and 2 was evaluated on anaesthetized cats. The results indicated that 1c caused a fall of 80 mm/Hg for >100' at a dose of 5mg/kg iv in anaesthetized cats.