Acute effect of moderate and high-intensity interval exercises on asprosin and BDNF levels in inactive normal weight and obese individuals.

This study aimed to examine the acute effects of moderate-intensity aerobic and high-intensity interval exercise protocols on Asprosin and Brain-Derived Neurotrophic Factor (BDNF) levels in inactive normal weight and obese individuals. A total of 20 male individuals aged 18-65 years, ten normal weight (NW) (Body Mass Index (BMI): 18.5-24.99 kg/m2) and 10 obese (Ob) (BMI: 24.99-35.00 kg/m2) participated in this study, voluntarily. Moderate aerobic exercise (AE) (main circuit 30 min, between 40 and 59% of Heart Rate Reserve: HRR) and High-Intensity Interval exercise (HIIE) running protocols (main circuit 20 min, between 75 and 90% of the HRR for 1 min*10 times, and 1-min active rest at 30% of the HRR) was applied to the volunteer participants in the morning hours (08.00-10.00 a.m.), following the night fasting (at least 8-10 h) for at least 3 days between each other. Blood samples were collected from the participants before and immediately after each exercise protocol, and serum asprosin and BDNF hormone levels were determined by Enzyme-Linked Immunosorbent Assay" method. Basal serum asprosin was found to be significantly higher in the Ob group compared to the NW group (p < .001), while the basal serum BDNF hormone was found to be lower (p < 0.05). It was observed that the serum asprosin level of both groups decreased significantly after both AE and HIIE protocols (p < 0.05). In addition, there was a significantly higher decrease in serum asprosin level in the Ob group compared to the NW group after HIIE protocol. For the Ob group, serum BDNF level increased considerably after HIIE protocol compared to AE protocol (p < 0.05). Serum asprosin was found to be higher in the Ob group, while the serum BDNF was found to be lower. In addition, the acute exercises of different intensity significantly affected hormones that regulate appetite metabolism. In particular, it was observed that the HIIE protocol had a greater effect on the regulation of appetite (hunger-satiety) in the Ob group. This result can be taken into account when planning training programs for these individuals.

An investigation of the relationship between new fasting hormone asprosin, obesity and acute-chronic exercise: current systematic review.

The purpose of this study was to reveal the relationship between new fasting hormone asprosin, obesity, and acute-chronic exercise. The prisma guidelines were followed in forming the methodological model of this review. The articles between 2016 and 2020 (including March) were identified by scanning Google Scholar, Pub Med, and Science Direct databases. Thirty-five articles were defined from 188 articles. Three cross-sectional, and 1 prospective cohort design studies in adults, and 3 cross-sectional studies in children were found. Three randomised-control group designed studies which examined the effect of acute exercise on serum asprosin levels in obese individuals. Asprosin may be a new therapeutic biomarker to be considered in the development, but long-term and deep-rooted researches are needed, and increasing the number of studies examining the effect of exercise on asprosin in the future might help us to identify the mechanisms underlying the decrease or increase in asprosin after exercise.

Assessment of acute aerobic exercise in the morning versus evening on asprosin, spexin, lipocalin-2, and insulin level in overweight/obese versus normal weight adult men.

The aim of this study was to examine the acute effect of aerobic exercise when performed in the morning and evening on obesity-related hormones of asprosin, spexin, lipocalin-2, and insulin in normal weight (NW) and overweight/obese (OW/OO) adults. A total of 20 adult male individuals (10 NW and 10 OW/OO) volunteered their participation. Both groups were subjected to an aerobic exercise protocol in moderate intensity (heart rate reserve of 55-59%) for 30 min at two different time periods of the day (morning: 08:00-10:00 h, evening: 20.00-22.00 h) at least 3 d apart. BeBis analysis revealed the OW/OO group consumed significantly less energy (1781.59 ± 410.71 kcal) as compared with NW group (2380.28 ± 445.50 kcal) before the evening exercise (about 3 d) (p <.05). As compared with the NW group, basal serum asprosin, insulin, and lipocalin-2 hormone levels were higher in the OW/OO group, and serum spexin level was lower in OW/OO group (p <.05). Body temperature significantly increased after morning and evening aerobic exercise in both groups. The increase in body temperature was significantly higher after the evening exercise in the OW/OO group compared to the NW group (p <.05). Significant decrease in serum asprosin lipocalin-2, and insulin levels was observed in both groups after exercise (p <.05). Evening aerobic exercise more greatly decreased serum asprosin, lipocalin-2, and insulin level in the OW/OO group as compared with the NW group (p <.05). In conclusion, it is thought that negative energy balance caused by psychological energy restriction and evening aerobic exercise, which leads to a further increase in body temperature, triggers greater decrease of orexigenic signals (suppression of appetite), and is more effective in the development of adipose tissue inflammation and insulin sensitivity, especially in OW/OO group.

Gender and maturation differences in health-related physical fitness and physical activity in Turkish children.

The aim of this study was to assess health - related physical fitness and physical activity parameters among children and to determine whether there were any significant gender and maturation differences. A total of 853 Turkish school children comprised of male prepubertal (n=212), female prepubertal (n=199), male pubertal (n=222) and female pubertal (n=218) children selected from the suburban schools of the Anatolian district of Istanbul were enrolled into this study. The health-related physical fitness properties included body composition, muscular strength, elasticity and aerobic fitness test and measurements. For estimation of the level of physical activity and daily energy expenditure the Bouchard's 3 day activity record was employed. The intensity of physical activity was divided into three groups with those having a MET of less than 4 considered sedentary, those with MET of 4-7 light while those with of MET >7 were considered to have Moderate-Vigorous Physical Activity (MVPA). The univariate 2 (gender) X 2 (maturation) ANOVA and co-variance tests were used to compare group means for body composition, physical fitness and physical activity. Evaluation of body fat ratio of the children revealed a significantly higher value for girls. The Max VO2 and handgrip strength was greater in the male gender while maturation differences showed a similar pattern favoring the pubertal period. The flexibility of the pubertal girls was significantly better than their male counterparts. The duration of physical activity was significantly longer in the males than female children. The duration of light activity among girls was longer than that of boys whereas the duration of MVPA in boys was significantly longer than that of girls. On the other hand the duration of MVPA among the prepubertal children was significantly higher than that of children in the pubertal period.

Effect of chronic exercise on immunoglobin, complement and leukocyte types in volleyball players and athletes.

BACKGROUND: The objective of this study was to investigate the effect of various sports disciplines on basic elements of the acquired and natural defense systems and to compare their results with that of non-sporting controls. MATERIALS/METHODS: The study included 15 sedentary (Group 1), 15 volleyball players (Group 2) and 15 long distance running athletes (Group 3). The VO2 Max for the groups was determined by subjecting the individuals to a 20 meter Shuttle run test. Immunoglobin and complement levels were measured by the turbidometric method. Leukocyte counts were made through peripheral blood smear examination. RESULTS: The IgA levels in sedentary living individuals was found to be lower than that in volleyball and athlete groups while that in athletes was in turn lower than that in volleyball players (p<0.05). In volleyball players the IgG level was significantly higher than both the sedentary living individuals and the athletes (p<0.05). IgM however, showed a significantly higher level in the sedentary group than in both athletes and volleyball players. The C3 levels in athletes was significantly lower than that of volleyball players and sedentary individuals (p<0.05), while the C4 levels were higher in the volleyball group (p<0.05). The leukocyte, eosinophil, and monocyte counts in the athletes were also significantly lower than those in the volleyball and sedentary groups (p<0.05). The values for the sedentary group on the other hand however, was found to be lower than those of the volleyball players (p<0.05). The neutrophil counts was lower in the sedentary group than in the volleyball group (p<0.05). The levels in the athlete group was lower than that in the volleyball group, however (p<0.05). The lymphocyte counts in volleyball players was higher than that in the sedentary group (p<0.05). CONCLUSIONS: In conclusion, changes in the immune parameters were found to be dependent on the type of physical exercise performed on regular basis. Considering the protective antibody response in those performing regular sports, moderate exercise carried out on regular basis can be said to affect positively mononuclear and polymorphonuclear phagocytic cells--the basic elements of the natural immune system.

Comparison of the effects of acute and regular exercise on intraocular pressure in Turkish athlete and sedentarians.

The aim of this study was to investigate the changes that take place in IOP in athletes and people leading sedentary lives subjected to aerobic and anaerobic exercise and how chronic exercise could affect these changes. The study included 20 sportsmen (Group 1), and 20 people leading sedentary lives (Group 2). The intensity of the exercise for both groups was determined according to the Karvonen protocol and executed as an aerobic exercise program involving running on a treadmill for 30 min. Subjects in both groups were subjected to anaerobic exercise according to the Wingate test protocol for 30 s. The intraocular pressure of all subjects before exercise and after aerobic and anaerobic exercise were measured. The IOP before and after exercise aerobic and anaerobic were evaluated by the Willcoxon test whereas the right and left IOP before exercise and after the aerobic and anaerobic exercise programs in both groups were evaluated using the Mann Whitney U test. p values of <.05 were considered significant. Significant differences were found when the pre-exercise and post-aerobic and anaerobic exercise IOPs of the groups were compared (p < .05). Comparison of the post-anaerobic and aerobic exercise revealed a fall in the IOPs of the subjects after the aerobic exercise (p < .01). In this study, exercise was found to lead to a fall in the IOP in both sportsmen and those leading sedentary lives with the fall less apparent under anaerobic conditions than under aerobic conditions. In conclusion, therefore, it can be said that in those with an increased intraocular pressure, regular, moderately intense aerobic exercise rather than short-lived intense exercise could be more useful.

Exercise intensity and its effects on thyroid hormones.

BACKGROUND: Physical activity influences energy metabolism in human subjects by increasing activity-induced energy expenditure and resting metabolic rate for several hours after exercise. Effects of exercise on circulating thyroid hormone values remain controversial. We have investigated the effect of acute aerobic exercise on thyroid hormone values. MATERIALS/METHODS: The effect of different intensity levels of acute aerobic exercise on thyroid hormones was investigated in 60 male well-trained athletes by performing bicycle ergometer at 45% (low intensity), 70% (moderate intensity), and 90% (high intensity). These intensities were selected according to their maximum heart rate (MHR). At each intensity level, heart rate, blood lactic acid, serum total thyroxine (T4), free thyroxine (fT4), total triiodothyronine (T3), free triiodothyronine (fT3) and thyroid stimulating hormone (TSH) values were measured. RESULTS: The results of this study show that exercise performed at the anaerobic threshold (70% of maximum heart rate, lactate level 4.59 +/- 1.75 mmol/l) caused the most prominent changes in the amount of any hormone values. While the rate of T4, fT4, and TSH continued to rise at 90% of maximum heart rate, the rate of T3 and fT3 started to fall. CONCLUSIONS: Maximal aerobic exercise greatly affects the level of circulating thyroid hormones.

The effects of exercise on the immune system and stress hormones in sportswomen.

BACKGROUND: Despite the numerous studies controversial results exist in specific immune response to exercise. The aim of this study was to determining the differences in the humoral immune parameters, serum ACTH and cortisol levels existing between sportswomen and sedentary subjects and the effect of acute aerobic and anaerobic exercise on these parameters. MATERIALS/METHODS: 40 sportswomen (Groups 1 and 2) and 20 sedentary women (Group 3) were enrolled and Group 1 performed aerobic exercise on a treadmill for 30 minutes while the Group 2 was subjected to the Wingate effort test for 30 seconds. Before exercising (at 8.30 a.m), immediately after the exercise, and 4 hours, days 2 and 5 days after exercising blood samples were obtained and the levels of IgA, IgG, IgM, complement 3 (C3) and complement 4 (C4) were determined turbidometrically. RESULTS: Before exercise: the means of IgA and IgG values in the G1 and G2 groups were higher than the Group G3, and the mean cortisol levels in the sedentary group was significantly higher (p<0.05). After Exercise: Whereas the C3 and C4 levels decreased significantly at the end of the exercise in Group 1 and 2 (p<0.05), the IgA, IgG (p<0.05) and IgM levels (p<0.01) at the 4th and 5th determinations were observed to be significantly higher in only the Group 1. The cortisol and ACTH levels were found to have increased significantly (p<0.05) in the Group 1. In Group 2, no changes were observed in the IgA, IgG and IgM levels. CONCLUSIONS: We conclude that regular and moderate exercise has favorable effects on the immune system by increasing immunoglobulins which are potent protective factors.