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Ann Pharm Fr ; 73(6): 401-10, 2015 Nov.
Article in French | MEDLINE | ID: mdl-26033567

ABSTRACT

Each year, in France, the number of cardiac arrests is evaluated between 30,000 to 50,000. When a patient survives, he undergoes a post-resuscitation syndrome which can aggravate the injuries and for which nowadays, no medication is available. In some kinds of cardiac arrest, a hypothermia protocol can be applied with a need for monitoring because of the appearance of side effects. In this context, hydrogen sulfide, which is a gasotransmitter with numerous physiological and pharmacological properties, may be interesting. Indeed, its use could protect against oxidative, inflammatory and apoptotic troubles induced by the post-resuscitation syndrome. The implied biochemical mechanisms are adenosine triphosphate potassium channels activation and cytochrome c oxidase inhibition. This molecule can also induce a suspended animation state characterized by a metabolism decrease, which could give a delay for physicians to start a therapeutic monitoring. Thus, in spite of a modest and sometimes contradictory literature, this compound could become the first neuroprotective molecule in cardiac arrest.


Subject(s)
Heart Arrest/complications , Hydrogen Sulfide/therapeutic use , Nervous System Diseases/etiology , Nervous System Diseases/prevention & control , Neuroprotection , Neuroprotective Agents/therapeutic use , Animals , Humans
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